Vitamin D and cancer risk and mortality: state of the science, gaps, and challenges

AM Mondul, SJ Weinstein, TM Layne… - Epidemiologic …, 2017 - academic.oup.com
There has been substantial enthusiasm recently regarding the potential role of vitamin D in
the primary and secondary prevention of cancer. Laboratory studies demonstrate a range of …

[PDF][PDF] Vitamin D receptor signaling and cancer

MJ Campbell, DL Trump - Endocrinology and metabolism clinics of North …, 2017 - Elsevier
The vitamin D receptor binds the seco-steroid hormone 1, 25 (OH) 2D3 with high affinity and
controls gene programs that include a significant component of the control of serum calcium …

Vitamin D receptor polymorphisms and cancer

P Gnagnarella, S Raimondi, V Aristarco… - Sunlight, Vitamin D and …, 2020 - Springer
Increasing scientific evidence supports the link between vitamin D and cancer risk. The
active metabolite 1, 25 (OH) 2D exerts its activity by binding to the vitamin D receptor (VDR) …

Effects of CYP2R1 gene variants on vitamin D levels and status: A systematic review and meta-analysis

L Duan, Z Xue, H Ji, D Zhang, Y Wang - Gene, 2018 - Elsevier
Background and objective CYP2R1 is a key gene in the vitamin D metabolic pathway. It has
been suggested that CYP2R1 gene variants in European populations are associated with …

Association between polymorphisms in vitamin d pathway-related genes, vitamin d status, muscle mass and function: A systematic review

E Krasniqi, A Boshnjaku, KH Wagner, B Wessner - Nutrients, 2021 - mdpi.com
An association between vitamin D level and muscle-related traits has been frequently
reported. Vitamin D level is dependent on various factors such as sunlight exposure and …

Genome-wide association study of serum 25-hydroxyvitamin D in US women

KM O'Brien, DP Sandler, M Shi, QE Harmon… - Frontiers in …, 2018 - frontiersin.org
Genetic factors likely influence individuals' concentrations of 25-hydroxyvitamin D [25 (OH)
D], a biomarker of vitamin D exposure previously linked to reduced risk of several chronic …

Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases

M Latacz, J Snarska, E Kostyra, E Fiedorowicz… - Nutrients, 2020 - mdpi.com
Vitamin D is widely known for its roles in the promotion of apoptosis and differentiation, with
simultaneous inhibition of proliferation, inflammation, angiogenesis, invasion, and …

Vitamin D metabolism gene polymorphisms and their associated disorders: a literature review

M Abouzid, F Główka, L Kagan… - Current Drug …, 2022 - ingentaconnect.com
Background: Vitamin D is a fat-soluble vitamin, and it is a potential key factor in maintaining
a healthy status. Various observational studies have reported the association between …

Is there a causal relationship between vitamin D and melanoma risk? A Mendelian randomization study

UE Liyanage, MH Law… - British Journal of …, 2020 - academic.oup.com
Background Several preclinical studies have identified the antiproliferative effects of 25‐
hydroxyvitamin D [25 (OH) D; vitamin D]. Ultraviolet radiation (UVR) is essential for vitamin D …

Identification of vitamin D3 target genes in human breast cancer tissue

L Sheng, PH Anderson, AG Turner, KI Pishas… - The Journal of steroid …, 2016 - Elsevier
Multiple epidemiological studies have shown that high vitamin D 3 status is strongly
associated with improved breast cancer survival. To determine the molecular pathways …