Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the
rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic …

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …

A major yet unresolved quest in decoding the human genome is the identification of the
regulatory sequences that control the spatial and temporal expression of genes. Distant …

Enhancers control the timing, location and expression levels of their target genes.
Nucleotide variation in enhancers has been shown to lead to numerous phenotypes …

JASPAR is a popular open-access database for matrix models describing DNA-binding
preferences for transcription factors and other DNA patterns. With its third major release …

Mammalian genomes are extensively transcribed outside the borders of protein-coding
genes. Genome-wide studies recently demonstrated that cis-regulatory genomic elements …

Clustering of multiple transcription factor binding sites (TFBSs) for the same transcription
factor (TF) is a common feature of cis-regulatory modules in invertebrate animals, but the …

Aligning and comparing genomic sequences enables the identification of conserved
sequence signatures and can enrich for coding and noncoding functional regions. In …

Abstract Recently, microRNAs (miRNA), small noncoding RNAs, have taken center stage in
the field of human molecular oncology. However, their roles in tumor biology remain largely …