Bioinformatics identification of TUBB as potential prognostic biomarker for worse prognosis in ERα-positive and better prognosis in ERα-negative breast cancer
R Alhammad - Diagnostics, 2022 - mdpi.com
Tubulin β class I gene (TUBB) is highly expressed in various cancers and plays several
roles in carcinogenesis. However, the prognostic value of TUBB in breast cancer remains to …
roles in carcinogenesis. However, the prognostic value of TUBB in breast cancer remains to …
Predictive value of PIMREG in the prognosis and response to immune checkpoint blockade of glioma patients
Glioma is the most common primary brain tumor in the human brain. The present study was
designed to explore the expression of PIMREG in glioma and its relevance to the …
designed to explore the expression of PIMREG in glioma and its relevance to the …
Higher levels of AKT-interacting protein in the frontal pole from people with schizophrenia are limited to a sub-group who have a marked deficit in cortical muscarinic …
M Snelleksz, B Dean - Psychiatry Research, 2024 - Elsevier
We are studying the molecular pathology of a sub-group within schizophrenia (∼ 25%:
termed Muscarinic Receptor Deficit subgroup of Schizophrenia (MRDS)) who can be …
termed Muscarinic Receptor Deficit subgroup of Schizophrenia (MRDS)) who can be …
Transmembrane and coiled-coil domains 3 is a diagnostic biomarker for predicting immune checkpoint blockade efficacy in hepatocellular carcinoma
Liver hepatocellular carcinoma (LIHC) is a malignancy with a high mortality and morbidity
rate worldwide. However, the pathogenesis of LIHC has still not been thoroughly studied …
rate worldwide. However, the pathogenesis of LIHC has still not been thoroughly studied …
Identifying genes associated with resistance to KRAS G12C inhibitors via machine learning methods
X Lin, QL Ma, L Chen, W Guo, Z Huang… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Background Targeted therapy has revolutionized cancer treatment, greatly improving patient
outcomes and quality of life. Lung cancer, specifically non-small cell lung cancer, is …
outcomes and quality of life. Lung cancer, specifically non-small cell lung cancer, is …
Tubulin alpha-1b chain was identified as a prognosis and immune biomarker in pan-cancer combing with experimental validation in breast cancer
Y Wang, Y Li, Y Jing, Y Yang, H Wang, D Ismtula… - Scientific Reports, 2024 - nature.com
The α-tubulin subtype, Tubulin α-1b chain (TUBA1B), has been shown to influence immune
cell infiltration, cancer growth, and survival across various malignancies. However, a …
cell infiltration, cancer growth, and survival across various malignancies. However, a …
Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities
Background Loss-of-function (LOF) alterations in tumour suppressor genes cannot be
directly targeted. Approaches characterising gene function and vulnerabilities conferred by …
directly targeted. Approaches characterising gene function and vulnerabilities conferred by …
Single-cell transcriptional atlas of tumor-associated macrophages in breast cancer
Background The internal heterogeneity of breast cancer, notably the tumor
microenvironment (TME) consisting of malignant and non-malignant cells, has been …
microenvironment (TME) consisting of malignant and non-malignant cells, has been …
mRNA-seq-based analysis predicts: AEG-1 is a therapeutic target and immunotherapy biomarker for pan-cancer, including OSCC
L Yao, L Liu, W Xu, H Xi, S Lin, G Piao, Y Liu… - Frontiers in …, 2024 - frontiersin.org
Background The aberrant expression of AEG-1 is significantly correlated with tumorigenesis,
development, neurodegeneration and inflammation. However, the relationship between …
development, neurodegeneration and inflammation. However, the relationship between …
Transcriptomic Approaches in Studies on and Applications of Chimeric Antigen Receptor T Cells
K Pierzynowska, L Gaffke, JM Zaucha, G Węgrzyn - Biomedicines, 2023 - mdpi.com
Chimeric antigen receptor T (CAR-T) cells are specifically modified T cells which bear
recombinant receptors, present at the cell surface and devoted to detect selected antigens of …
recombinant receptors, present at the cell surface and devoted to detect selected antigens of …