Beyond specific limits of exposure, chemical entities can provoke deleterious effects in
mammalian cells via direct interaction with critical macromolecules or by stimulating the …

Systems Toxicology aims to change the basis of how adverse biological effects of
xenobiotics are characterized from empirical end points to describing modes of action as …

We describe and illustrate a workflow for chemical safety assessment that completely avoids
animal testing. The workflow, which was developed within the SEURAT-1 initiative, is …

Polycyclic aromatic hydrocarbons (PAHs) may interact with multiple intracellular receptors
and related signaling pathways. We comprehensively evaluated the toxicity profiles of six …

Adaptive cellular stress responses are paramount in the healthy control of cell and tissue
homeostasis and generally activated during toxicity in a chemical-specific manner. Here, we …

The utilisation of genome-wide transcriptomics has played a pivotal role in advancing the
field of toxicology, allowing the mapping of transcriptional signatures to chemical exposures …

Cellular resilience describes the ability of a cell to cope with environmental changes such as
toxicant exposure. If cellular metabolism does not collapse directly after the hit or end in …

Cadmium is a well-studied environmental pollutant where the kidney and particularly the
proximal tubule cells are especially sensitive as they are exposed to higher concentrations …

The blood-brain barrier (BBB) is a highly restrictive barrier that preserves central nervous
system homeostasis and ensures optimal brain functioning. Using BBB cell assays makes it …

Toxicological responses to chemical insult are largely regulated by transcriptionally
activated pathways that may be independent, correlated and partially or fully overlapping …