Long-term effects of SARS-CoV-2 in the brain: clinical consequences and molecular mechanisms
AC Granholm - Journal of Clinical Medicine, 2023 - mdpi.com
Numerous investigations have demonstrated significant and long-lasting neurological
manifestations of COVID-19. It has been suggested that as many as four out of five patients …
manifestations of COVID-19. It has been suggested that as many as four out of five patients …
Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model
Down syndrome (DS), the genetic condition caused by trisomy 21, is characterized by
variable cognitive impairment, immune dysregulation, dysmorphogenesis and increased …
variable cognitive impairment, immune dysregulation, dysmorphogenesis and increased …
Blood biomarkers for Alzheimer's disease in Down syndrome
Epidemiological evidence suggests that by the age of 40 years, all individuals with Down
syndrome (DS) have Alzheimer's disease (AD) neuropathology. Clinical diagnosis of …
syndrome (DS) have Alzheimer's disease (AD) neuropathology. Clinical diagnosis of …
Resistance training and Down Syndrome: A narrative review on considerations for exercise prescription and safety
The current manuscript reviews the literature on the health effects of resistance training (RT)
for individuals with Down syndrome (DS), focusing on this training modality's methodology …
for individuals with Down syndrome (DS), focusing on this training modality's methodology …
Obstructive sleep apnoea in children with Down syndrome: a multidisciplinary approach
A comprehensive evaluation of obstructive sleep apnoea (OSA) may allow for the
development of more efficient management of Down syndrome (DS). We aimed to evaluate …
development of more efficient management of Down syndrome (DS). We aimed to evaluate …
COVID-19 vaccination of individuals with Down syndrome—data from the Trisomy 21 Research Society Survey on safety, efficacy, and factors associated with the …
A Hüls, PT Feany, SI Zisman, ACS Costa, M Dierssen… - Vaccines, 2022 - mdpi.com
Individuals with Down syndrome (DS) are among the groups with the highest risk for severe
COVID-19. Better understanding of the efficacy and risks of COVID-19 vaccines for …
COVID-19. Better understanding of the efficacy and risks of COVID-19 vaccines for …
Neuropathological findings in Down syndrome, Alzheimer's disease and control patients with and without SARS-COV-2: preliminary findings
ACE Granholm, E Englund, A Gilmore, E Head… - Acta …, 2024 - Springer
The SARS-CoV-2 virus that led to COVID-19 is associated with significant and long-lasting
neurologic symptoms in many patients, with an increased mortality risk for people with …
neurologic symptoms in many patients, with an increased mortality risk for people with …
Susceptibility to COVID-19 diagnosis in people with down syndrome compared to the general population: matched-cohort study using primary care electronic records …
Background During the COVID-19 pandemic, people with Down syndrome (DS) have
experienced a more severe disease course and higher mortality rates than the general …
experienced a more severe disease course and higher mortality rates than the general …
Safety and long-term immunogenicity of BNT162b2 vaccine in individuals with down syndrome
D Valentini, N Cotugno, V Scoppola… - Journal of Clinical …, 2022 - mdpi.com
We aimed to evaluate the safety and immunogenicity of the BNT162b2 vaccine in young
people with Down syndrome (DS), and to compare their humoral immune response with …
people with Down syndrome (DS), and to compare their humoral immune response with …
Comparison of COVID-19 and non-COVID-19 pneumonia in Down syndrome
D Real de Asua, MA Mayer, MC Ortega… - Journal of clinical …, 2021 - mdpi.com
Whether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and
death observed in Down syndrome (DS) are disease specific or also occur in individuals …
death observed in Down syndrome (DS) are disease specific or also occur in individuals …