Positive effects from sports are achieved primarily through physical activity, but secondary
effects bring health benefits such as psychosocial and personal development and less …

While the central nervous system compromises 2% of our body weight, it harbors up to 25%
of the body's cholesterol. Cholesterol levels in the brain are tightly regulated for …

Cholesterol is an indispensable component of the cell membrane and plays vital roles in
critical physiological processes. Brain cholesterol accounts for a large portion of total …

Background Dementia is a prevalent condition, affecting 5–7% of people aged 60 years and
older, and a leading cause of disability in people aged 60 years and older globally. We …

Background Uncertainty remains concerning the association of blood cholesterol with the
risk of subsequent dementia. Using data from people with lipid measurements in the UK …

A decade has passed since we published a comprehensive review in this journal
addressing the topic of promoting successful cognitive aging, making this a good time to …

Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the
deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the …

Nearly 30% of adults 40 years and older in the United States are on a statin. Their
widespread use heightens the importance of careful consideration of their varied effects on …

Alzheimer's disease is the most common form of dementia, and the prodromal phases of
Alzheimer's disease can last for decades. Vascular dementia is the second most common …

Background With no effective treatments for cognitive decline or dementia, improving the
evidence base for modifiable risk factors is a research priority. This study investigated …