Latest developments in molecular tracers for fluorescence image-guided cancer surgery
Real-time intraoperative guidance is essential during oncological surgery for complete and
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …
Nanobodies and nanobody-based human heavy chain antibodies as antitumor therapeutics
P Bannas, J Hambach, F Koch-Nolte - Frontiers in immunology, 2017 - frontiersin.org
Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells
in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal …
in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal …
Method to diversify cyanine chromophore functionality enables improved biomolecule tracking and intracellular imaging
Heptamethine indocyanines are invaluable probes for near-infrared (NIR) imaging. Despite
broad use, there are only a few synthetic methods to assemble these molecules, and each …
broad use, there are only a few synthetic methods to assemble these molecules, and each …
Amyloid-β and tau complexity—towards improved biomarkers and targeted therapies
JC Polanco, C Li, LG Bodea… - Nature Reviews …, 2018 - nature.com
Most neurodegenerative diseases are proteinopathies, which are characterized by the
aggregation of misfolded proteins. Although many proteins have an intrinsic propensity to …
aggregation of misfolded proteins. Although many proteins have an intrinsic propensity to …
Doubly Strapped Zwitterionic NIR‐I and NIR‐II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging
Heptamethine cyanine dyes enable deep tissue fluorescence imaging in the near infrared
(NIR) window. Small molecule conjugates of the benchmark dye ZW800‐1 have been tested …
(NIR) window. Small molecule conjugates of the benchmark dye ZW800‐1 have been tested …
Nanobody: outstanding features for diagnostic and therapeutic applications
JP Salvador, L Vilaplana, MP Marco - Analytical and bioanalytical …, 2019 - Springer
Nanobodies (Nbs) have arisen as an alternative to conventional antibodies (Abs) and show
great potential when used as tools in different biotechnology fields such as diagnostics and …
great potential when used as tools in different biotechnology fields such as diagnostics and …
[HTML][HTML] Size and affinity kinetics of nanobodies influence targeting and penetration of solid tumours
P Debie, C Lafont, M Defrise, I Hansen… - Journal of Controlled …, 2020 - Elsevier
A compound's intratumoural distribution is an important determinant for the effectiveness of
molecular therapy or imaging. Antibodies (Abs), though often used in the design of targeted …
molecular therapy or imaging. Antibodies (Abs), though often used in the design of targeted …
[PDF][PDF] Nanobody—A versatile tool for cancer diagnosis and therapeutics
M Liu, L Li, D Jin, Y Liu - Wiley Interdisciplinary Reviews …, 2021 - researchgate.net
In spite of the successful use of monoclonal antibodies (mAbs) in clinic for tumor treatment,
their applications are still hampered in therapeutic development due to limitations, such as …
their applications are still hampered in therapeutic development due to limitations, such as …
Nanobodies: robust miniprotein binders in biomedicine
Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
Sterically shielded heptamethine cyanine dyes for bioconjugation and high performance near‐infrared fluorescence imaging
The near‐infrared window of fluorescent heptamethine cyanine dyes greatly facilitates
biological imaging because there is deep penetration of the light and negligible background …
biological imaging because there is deep penetration of the light and negligible background …