Big data in chemical toxicity research: the use of high-throughput screening assays to identify potential toxicants
High-throughput screening (HTS) assays that measure the in vitro toxicity of environmental
compounds have been widely applied as an alternative to in vivo animal tests of chemical …
compounds have been widely applied as an alternative to in vivo animal tests of chemical …
From cutting edge to guideline: A first step in harmonization of the zebrafish embryotoxicity test (ZET) by describing the most optimal test conditions and morphology …
M Beekhuijzen, C de Koning, ME Flores-Guillén… - Reproductive …, 2015 - Elsevier
In the last couple of years, the interest in the zebrafish embryotoxicity test (ZET) for use in
developmental toxicity assessment has been growing exponentially. This is also evident …
developmental toxicity assessment has been growing exponentially. This is also evident …
Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo
IWT Selderslaghs, AR Van Rompay, W De Coen… - Reproductive …, 2009 - Elsevier
We developed and optimized a screening procedure, in which zebrafish embryos were
explored as a model for the evaluation of the specific embryotoxic and teratogenic potential …
explored as a model for the evaluation of the specific embryotoxic and teratogenic potential …
[HTML][HTML] Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies
SAB Hermsen, EJ van den Brandhof, LTM van der Ven… - Toxicology in Vitro, 2011 - Elsevier
The zebrafish embryotoxicity test (ZET) is a fast and simple method to study chemical toxicity
after exposure of the complete vertebrate embryo during embryogenesis in ovo. We …
after exposure of the complete vertebrate embryo during embryogenesis in ovo. We …
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing
D Basketter, H Clewell, I Kimber, A Rossi… - 2012 - wellbeingintlstudiesrepository.org
Systemic toxicity testing forms the cornerstone for the safety evaluation of substances.
Pressures to move from traditional animal models to novel technologies arise from various …
Pressures to move from traditional animal models to novel technologies arise from various …
[HTML][HTML] Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms
M Ouedraogo, T Baudoux, C Stévigny, J Nortier… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The increasing use of traditional herbal
medicines around the world requires more scientific evidence for their putative …
medicines around the world requires more scientific evidence for their putative …
Shape and steepness of toxicological dose–response relationships of continuous endpoints
W Slob, RW Setzer - Critical reviews in toxicology, 2014 - Taylor & Francis
A re-analysis of a large number of historical dose–response data for continuous endpoints
indicates that an exponential or a Hill model with four parameters adequately describes …
indicates that an exponential or a Hill model with four parameters adequately describes …
Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the US EPA's ToxRefDB
As the primary source for regulatory developmental toxicity information, prenatal studies
characterize maternal effects and fetal endpoints including malformations, resorptions, and …
characterize maternal effects and fetal endpoints including malformations, resorptions, and …
Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental …
E de Jong, M Barenys, SAB Hermsen, A Verhoef… - Toxicology and applied …, 2011 - Elsevier
The relatively high experimental animal use in developmental toxicity testing has stimulated
the search for alternatives that are less animal intensive. Three widely studied alternative …
the search for alternatives that are less animal intensive. Three widely studied alternative …
High-throughput screening for analysis of in vitro toxicity
WG Schoonen, WM Westerink, GJ Horbach - Exs, 2009 - Springer
The influence of combinatorial chemistry and high-throughput screening (HTS) technologies
in the pharmaceutical industry during the last 10 years has been enormous. However, the …
in the pharmaceutical industry during the last 10 years has been enormous. However, the …