Transmission, development, and plasticity of synapses

KP Harris, JT Littleton - Genetics, 2015 - academic.oup.com
Chemical synapses are sites of contact and information transfer between a neuron and its
partner cell. Each synapse is a specialized junction, where the presynaptic cell assembles …

SNARE regulatory proteins in synaptic vesicle fusion and recycling

CW Sauvola, JT Littleton - Frontiers in molecular neuroscience, 2021 - frontiersin.org
Membrane fusion is a universal feature of eukaryotic protein trafficking and is mediated by
the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family …

Sequential N‐to C‐terminal SNARE complex assembly drives priming and fusion of secretory vesicles

JB Sørensen, K Wiederhold, EM Müller… - The EMBO …, 2006 - embopress.org
During exocytosis a four‐helical coiled coil is formed between the three SNARE proteins
syntaxin, synaptobrevin and SNAP‐25, bridging vesicle and plasma membrane. We have …

The molecular machinery of synaptic vesicle exocytosis

L Li, LS Chin - Cellular and Molecular Life Sciences CMLS, 2003 - Springer
At the synapse, neurotransmitters are released via Ca 2+-triggered exocytotic fusion of
synaptic vesicles with the presynaptic plasma membrane. Synaptic vesicle exocytosis …

Astrocyte growth is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor

J Chen, T Stork, Y Kang, KAM Nardone, F Auer… - Neuron, 2024 - cell.com
Astrocytes play crucial roles in regulating neural circuit function by forming a dense network
of synapse-associated membrane specializations, but signaling pathways regulating …

Molecular underpinnings of synaptic vesicle pool heterogeneity

DC Crawford, ET Kavalali - Traffic, 2015 - Wiley Online Library
Neuronal communication relies on chemical synaptic transmission for information transfer
and processing. Chemical neurotransmission is initiated by synaptic vesicle fusion with the …

The synaptic vesicle cycle: exocytosis and endocytosis in Drosophila and C. elegans

JE Richmond, KS Broadie - Current opinion in neurobiology, 2002 - Elsevier
Advances in the study of Drosophila melanogaster and Caenorhabditis elegans have
provided key insights into the processes of neurotransmission and neuromodulation. Work …

Members of the synaptobrevin/vesicle-associated membrane protein (VAMP) family in Drosophila are functionally interchangeable in vivo for neurotransmitter …

S Bhattacharya, BA Stewart… - Proceedings of the …, 2002 - National Acad Sciences
Synaptobrevins or VAMPs are vesicle-associated membrane proteins, often called v-
SNARES, that are important for vesicle transport and fusion at the plasma membrane …

Mating, seminal fluid components, and sperm cause changes in vesicle release in the Drosophila female reproductive tract

Y Heifetz, MF Wolfner - Proceedings of the National …, 2004 - National Acad Sciences
Mating induces changes in female insects, including in egg production, ovulation and laying,
sperm storage, and behavior. Several molecules and effects that induce these changes …

A signaling mechanism coupling netrin-1/deleted in colorectal cancer chemoattraction to SNARE-mediated exocytosis in axonal growth cones

T Cotrufo, F Pérez-Brangulí, A Muhaisen… - Journal of …, 2011 - Soc Neuroscience
Directed cell migration and axonal guidance are essential steps in neural development.
Both processes are controlled by specific guidance cues that activate the signaling …