Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Recent studies have
identified the key role of crosstalk between dysregulated epithelial cells, mesenchymal …

Rheumatoid arthritis (RA) is a destructive, systemic, inflammatory disorder that
characteristically affects small, diarthrodial joints in a progressive, symmetric, and erosive …

Intestinal fibrosis is considered an inevitable complication of Crohn's disease (CD) that
results in symptoms of obstruction and stricture formation. Endoscopic or surgical treatment …

Human interferon gamma is a cytokine belonging to a diverse group of interferons which
have a crucial immunological function against mycobacteria and a wide variety of viral …

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease (ILD) of unknown
origin characterized by epithelial cell dysfunctions, accumulation of fibroblasts and …

Hepatic stellate cells play a crucial role in the pathogenesis of hepatic fibrosis. Thus,
pharmacological inhibition of pro-fibrotic activities of these cells might lead to an effective …

Patients receiving thoracic radiation often develop pulmonary injury and fibrosis. Currently,
there are no effective measures to prevent or treat these conditions. We tested whether …

Interstitial lung diseases (ILD) represent a group of heterogeneous parenchymal lung
disorders with complex pathophysiology, characterized by different clinical and radiological …

Interferon gamma (IFNγ) is a potent cytokine that displays a variety of anti-viral, anti-
proliferative, immunomodulatory, apoptotic and anti-fibrotic functions. However, its clinical …

Type I IFNs play a critical role in the immune response to viral infection and may also drive
autoimmunity through modulation of monocyte maturation and promotion of autoreactive …