1, 3, 4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic
molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …

Nowadays, an increasing number of heterocyclic-based drugs found application in
medicinal chemistry and, in particular, as anticancer agents. In this context, oxadiazoles …

A new series of non-carboxylic naproxen analogues, bearing a variety of ring systems, such
as oxadiazoles 3a–c and 6a–c, cycloalkanes 4a–d, cyclic imides 5a–c, and triazoles 7–9 …

Clinical and preclinical data reveal that RECQL5 protein overexpression in breast cancer
was strongly correlated with poor prognosis, survival, and therapeutic resistance. In the …

The aim of our study was to investigate the potential of rutin, catechin, dehydrozingerone,
naringenin, and quercetin, both alone and in combination with temozolomide, to inhibit the …

Lung cancer is the leading type of malignancy in terms of occurrence and mortality in the
global context. STAT3 is an oncogenic transcription factor that is persistently activated in …

Periodontal disease (PD) is multifactorial oral disease that damages tooth-supporting tissue.
PD treatment includes proper oral hygiene, deep cleaning, antibiotics therapy, and surgery …

Abstract New α, β-unsaturated-2, 5-disubstituted-1, 3, 4-Oxadiazoles (4a–j) and (10a–d)
have been prepared in good to excellent yields starting from β-chlorovinyl aldehydes and …

Oxadiazole is a fascinating heterocyclic compound with a unique five-membered ring
structure containing nitrogen and oxygen atoms. It has garnered significant attention for its …

Inclining mortality with a constant plummet in the survival rates associated with glioblastoma
still stands as an inveterate predicament. The only promising therapy with temozolomide …