Hemophagocytic lymphohistiocytosis (HLH) is a disorder that has been recognized since the
middle of the last century. In recent decades, increasing understanding of the genetic roots …

Acute liver failure (ALF) is a rare, rapidly evolving, clinical syndrome with devastating
consequences where definitive treatment is by emergency liver transplantation. Establishing …

Upon infection, severe acute respiratory syndrome—coronavirus 2 (SARS-CoV-2) is
predicted to interact with diverse cellular functions, such as the nonsense-mediated decay …

Circular RNAs (circRNAs) arise from precursor mRNA processing through back-splicing and
have been increasingly recognized for their functions in various cancers including acute …

Nonsense variants can inactivate gene function by causing the synthesis of truncated
proteins or by inducing nonsense mediated decay of messenger RNAs. The occurrence of …

Secondary hemophagocytic lymphohistiocytosis (sHLH) is a hyperinflammatory syndrome
characterized by immune disorders. It is imperative to elucidate the immunophenotypic …

Mutations in the neuroblastoma amplified sequence (NBAS) gene correlate with infantile
acute liver failure (ALF). Herein, we identified a novel NBAS mutation in a female infant …

Since the first report of SOPH syndrome among the Yakut population in 2010, new clinical
data of SOPH‐like conditions continue to appear. We expand the phenotypic spectrum of …

Hemophagocytic lymphohistiocytosis (HLH) is a multisystem involvement,
hyperinflammatory state with rapid progression and a poor outcome. However, HLH may …

Aims: FK506-binding protein like (FKBPL) and its therapeutic peptide mimetic, AD-01, are
crucial negative regulators of angiogenesis, yet the underlying mechanisms involved in …