Methyl-CpG-binding domain proteins: readers of the epigenome
How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond
L Luzhna, P Kathiria, O Kovalchuk - Frontiers in genetics, 2013 - frontiersin.org
Micronuclei (MN) are extra-nuclear bodies that contain damaged chromosome fragments
and/or whole chromosomes that were not incorporated into the nucleus after cell division …
and/or whole chromosomes that were not incorporated into the nucleus after cell division …
Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation
S Kaluscha, S Domcke, C Wirbelauer, MB Stadler… - Nature …, 2022 - nature.com
Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
Genomic DNA methylation: the mark and its mediators
Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in
the mammalian genome and is essential for embryonic viability. With several of the key …
the mammalian genome and is essential for embryonic viability. With several of the key …
Epigenetic mechanisms in mammals
JK Kim, M Samaranayake, S Pradhan - Cellular and molecular life …, 2009 - Springer
DNA and histone methylation are linked and subjected to mitotic inheritance in mammals.
Yet how methylation is propagated and maintained between successive cell divisions is not …
Yet how methylation is propagated and maintained between successive cell divisions is not …
DNA methylation and methyl-CpG binding proteins: developmental requirements and function
O Bogdanović, GJC Veenstra - Chromosoma, 2009 - Springer
DNA methylation is a major epigenetic modification in the genomes of higher eukaryotes. In
vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and …
vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and …
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary
Abstract The 5-methylcytosine (5-mC) derivative 5-hydroxymethylcytosine (5-hmC) is
abundant in the brain for unknown reasons. Here we characterize the genomic distribution …
abundant in the brain for unknown reasons. Here we characterize the genomic distribution …
The current state of eukaryotic DNA base damage and repair
DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar,
and single-strand break damage resulting from oxidation, alkylation, deamination, and …
and single-strand break damage resulting from oxidation, alkylation, deamination, and …
DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases
T Morales-Ruiz, AP Ortega-Galisteo… - Proceedings of the …, 2006 - National Acad Sciences
Cytosine methylation is an epigenetic mark that promotes gene silencing and plays
important roles in development and genome defense against transposons. Methylation …
important roles in development and genome defense against transposons. Methylation …
DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG
RJ Klose, SA Sarraf, L Schmiedeberg, SM McDermott… - Molecular cell, 2005 - cell.com
DNA methylation is interpreted by a family of methyl-CpG binding domain (MBD) proteins
that repress transcription through recruitment of corepressors that modify chromatin. To …
that repress transcription through recruitment of corepressors that modify chromatin. To …