The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer
The TYRO3, AXL (also known as UFO) and MERTK (TAM) family of receptor tyrosine
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …
Giving AXL the axe: targeting AXL in human malignancy
The receptor tyrosine kinase AXL, activated by a complex interaction between its ligand
growth arrest-specific protein 6 and phosphatidylserine, regulates various vital cellular …
growth arrest-specific protein 6 and phosphatidylserine, regulates various vital cellular …
Genetics and biomarkers in personalisation of lung cancer treatment
R Rosell, TG Bivona, N Karachaliou - The Lancet, 2013 - thelancet.com
Non-small-cell lung cancer is often diagnosed at the metastatic stage, with median survival
of just 1 year. The identification of driver mutations in the epidermal growth factor receptor …
of just 1 year. The identification of driver mutations in the epidermal growth factor receptor …
MYC instructs and maintains pancreatic adenocarcinoma phenotype
The signature features of pancreatic ductal adenocarcinoma (PDAC) are its
fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that acute …
fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that acute …
Reprogramming the immunological microenvironment through radiation and targeting Axl
Increasing evidence suggests that ionizing radiation therapy (RT) in combination with
checkpoint immunotherapy is highly effective in treating a subset of cancers. To better …
checkpoint immunotherapy is highly effective in treating a subset of cancers. To better …
[HTML][HTML] AXL kinase as a novel target for cancer therapy
X Wu, X Liu, S Koul, CY Lee, Z Zhang, B Halmos - Oncotarget, 2014 - ncbi.nlm.nih.gov
The AXL receptor tyrosine kinase and its major ligand, GAS6 have been demonstrated to be
overexpressed and activated in many human cancers (such as lung, breast, and pancreatic …
overexpressed and activated in many human cancers (such as lung, breast, and pancreatic …
AXL mediates resistance to cetuximab therapy
TM Brand, M Iida, AP Stein, KL Corrigan… - Cancer research, 2014 - AACR
The EGFR antibody cetuximab is used to treat numerous cancers, but intrinsic and acquired
resistance to this agent is a common clinical outcome. In this study, we show that …
resistance to this agent is a common clinical outcome. In this study, we show that …
[HTML][HTML] Axl as a mediator of cellular growth and survival
H Axelrod, KJ Pienta - Oncotarget, 2014 - ncbi.nlm.nih.gov
The control of cellular growth and proliferation is key to the maintenance of homeostasis.
Survival, proliferation, and arrest are regulated, in part, by Growth Arrest Specific 6 (Gas6) …
Survival, proliferation, and arrest are regulated, in part, by Growth Arrest Specific 6 (Gas6) …
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction
M DeBerge, K Glinton, M Subramanian… - The Journal of …, 2021 - Am Soc Clin Investig
Tyro3, AXL, and MerTK (TAM) receptors are activated in macrophages in response to tissue
injury and as such have been proposed as therapeutic targets to promote inflammation …
injury and as such have been proposed as therapeutic targets to promote inflammation …
Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib
Elevated expression and activity of the epidermal growth factor receptor (EGFR) is
associated with development and progression of head and neck cancer (HNC) and a poor …
associated with development and progression of head and neck cancer (HNC) and a poor …