Background and Purpose Chemogenomics focuses on the discovery of new connections
between chemical and biological space leading to the discovery of new protein targets and …

Smaller stones with a wide variety of colors make a higher resolution mosaic. In much the
same way, smaller chemical entities that are structurally diverse are better able to …

Virtual fragment screening (VFS) is a promising new method that uses computer models to
identify small, fragment-like biologically active molecules as useful starting points for …

Introduction/history 3. H4R gene 4. H4R expression profile 5. H4R protein structure and post-
translational modifications 5.1. H4R assembly in the cell membrane 6. H4R ligands 6.1. H4R …

The histamine H4 receptor (H4R) is a G protein-coupled receptor (GPCR) that plays an
important role in inflammation. Similar to the homologous histamine H3 receptor (H3R), two …

We have explored the possibilities and challenges of structure-based virtual screening
(SBVS) against the human histamine H4 receptor (H4R), a key player in inflammatory …

Background and Purpose The recently proposed binding mode of 2‐aminopyrimidines to
the human (h) histamine H4 receptor suggests that the 2‐amino group of these ligands …

We describe the development of novel benzimidazoles as small molecule histamine H4
receptor (H4R) antagonists and their profiling in rat early toxicity studies. The discovery and …

The increasing number of G protein-coupled receptor (GPCR) crystal structures offers new
opportunities for histamine receptor homology modeling. However, computational prediction …

One of well-established biological activities for chalcone derivatives is as
acetylcholinesterase inhibitors, which can be developed for the therapy of Alzheimer's …