Inflammation‐related mechanisms in chronic kidney disease prediction, progression, and outcome

S Mihai, E Codrici, ID Popescu… - Journal of …, 2018 - Wiley Online Library
Persistent, low‐grade inflammation is now considered a hallmark feature of chronic kidney
disease (CKD), being involved in the development of all‐cause mortality of these patients …

Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

A Levin, M Tonelli, J Bonventre, J Coresh, JA Donner… - The Lancet, 2017 - thelancet.com
The global nephrology community recognises the need for a cohesive plan to address the
problem of chronic kidney disease (CKD). In July, 2016, the International Society of …

Extracellular matrix in kidney fibrosis: more than just a scaffold

RD Bülow, P Boor - Journal of Histochemistry & …, 2019 - journals.sagepub.com
Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

[HTML][HTML] Diagnosis of diabetic kidney disease: state of the art and future perspective

F Persson, P Rossing - Kidney international supplements, 2018 - Elsevier
Approximately 20% to 40% of patients with type 1 or type 2 diabetes mellitus develop
diabetic kidney disease. This is a clinical syndrome characterized by persistent albuminuria …

Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective …

N Tofte, M Lindhardt, K Adamova… - The lancet Diabetes & …, 2020 - thelancet.com
Background Microalbuminuria is an early sign of kidney disease in people with diabetes and
indicates increased risk of cardiovascular disease. We tested whether a urinary proteomic …

Novel biomarkers in the diagnosis of chronic kidney disease and the prediction of its outcome

J Rysz, A Gluba-Brzózka, B Franczyk… - International journal of …, 2017 - mdpi.com
In its early stages, symptoms of chronic kidney disease (CKD) are usually not apparent.
Significant reduction of the kidney function is the first obvious sign of disease. If diagnosed …

Proteomics and metabolomics in kidney disease, including insights into etiology, treatment, and prevention

RF Dubin, EP Rhee - Clinical Journal of the American Society of …, 2020 - journals.lww.com
In this review of the application of proteomics and metabolomics to kidney disease research,
we review key concepts, highlight illustrative examples, and outline future directions. The …

Peptidomics and proteomics based on CE‐MS as a robust tool in clinical application: The past, the present, and the future

A Latosinska, J Siwy, H Mischak, M Frantzi - Electrophoresis, 2019 - Wiley Online Library
Capillary electrophoresis combined with mass spectrometry (CE‐MS) has been used for
several years for the investigation of proteins and peptides as biomarkers for diagnosis and …

[HTML][HTML] 2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications

N Gonzalez, I Prieto, L del Puerto-Nevado… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Worldwide deaths from diabetes mellitus (DM) and colorectal cancer increased by 90% and
57%, respectively, over the past 20 years. The risk of colorectal cancer was estimated to be …

A urinary proteome-based classifier for the early detection of decline in glomerular filtration

C Pontillo, L Jacobs, JA Staessen… - Nephrology Dialysis …, 2017 - academic.oup.com
Background. Chronic kidney disease (CKD) progression is currently assessed by a decline
in estimated glomerular filtration rate (eGFR) and/or an increase in urinary albumin excretion …