Differential gene expression mechanisms ensure cellular differentiation and plasticity to
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …

Precise patterns of gene expression in metazoans are controlled by three classes of
regulatory elements: promoters, enhancers and boundary elements. During differentiation …

CTCF is crucial to the organization of mammalian genomes into loop structures. According
to recent studies, the transcription apparatus is compartmentalized and concentrated at …

The three-dimensional arrangement of the human genome comprises a complex network of
structural and regulatory chromatin loops important for coordinating changes in transcription …

Enhancer-mediated gene activation generally requires physical proximity between
enhancers and their target gene promoters. However, the molecular mechanisms by which …

The GATA family of transcription factors is of crucial importance during embryonic
development, playing complex and widespread roles in cell fate decisions and tissue …

Enhancers establish spatial or temporal patterns of gene expression that are critical for
development, yet our understanding of how these DNA cis-regulatory elements function from …

Chromatin interactions connect distal regulatory elements to target gene promoters guiding
stimulus-and lineage-specific transcription. Few factors securing chromatin interactions have …

The early stages of type 1 diabetes (T1D) are characterized by local autoimmune
inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show …

Changes in the pattern of gene expression play an important role in allowing cancer cells to
acquire their hallmark characteristics, while genomic instability enables cells to acquire …