We have developed a general profile for the proteins of the TetR family of repressors. The
stretch that best defines the profile of this family is made up of 47 amino acid residues that …

While the biological functions of most of the secondary metabolites made by streptomycetes
are not known, it is inconceivable that they do not play an adaptive ecological role. The …

Abstract A-factor (2-isocapryloyl-3 R-hydroxymethyl-γ-butyrolactone) is a microbial hormone
that triggers aerial mycelium formation and secondary metabolism in Streptomyces griseus …

Gamma‐butyrolactone signalling molecules are produced by many Streptomyces species,
and several have been shown to regulate antibiotic production. In Streptomyces coelicolor …

In Streptomyces coelicolor, bldA encodes the only tRNA for a rare leucine codon, UUA. This
tRNA is unnecessary for growth, but is required for some aspects of secondary metabolism …

The complex morphogenesis of the bacterial genus Streptomyces has made this genus a
model prokaryote for study of multicellular differentiation, and its ability to produce a wide …

Selman Waksman's seminal discovery that streptomycin, a natural product produced by
Streptomyces griseus, 1 could be used to treat tuberculosis set the stage for decades of …

Streptomyces griseus, a well-known industrial producer of streptomycin, is a member of the
genus Streptomyces, which shows a complex life cycle resembling that of fungi. A-factor, a …

The developmentally complex soil microbe Streptomyces tendae secretes a hydrophobic
peptide that restored to developmental mutants of S. coelicolor the ability to raise aerial …

Our recent identification and genetic analysis of the biosynthetic gene cluster for production
of the ribosomally synthesized and posttranslationally modified peptide cypemycin revealed …