The structural elucidation of small molecules using mass spectrometry plays an important
role in modern life sciences and bioanalytical approaches. This review covers different soft …

Since its introduction, the orbitrap has proven to be a robust mass analyzer that can routinely
deliver high resolving power and mass accuracy. Unlike conventional ion traps such as the …

We performed a large scale study of electron transfer dissociation (ETD) performance, as
compared with ion trap collision-activated dissociation (CAD), for peptides ranging from∼ …

For about three decades, the chemistry of cation radicals derived from organic molecules
had received a major impetus from mass spectrometry. This was because cation radicals …

Despite major advantages in the field of proteomics, the analysis of PTMs still poses a major
challenge; thus far, preventing insights into the role and regulation of protein networks …

Mass spectrometry has rapidly evolved to become the platform of choice for proteomic
analysis. While CID remains the major fragmentation method for peptide sequencing …

Ambient mass spectrometry, pioneered with desorption electrospray ionization (DESI)
technique, is of increasing interest in recent years. In this study, a corona discharge …

Fatty acids (FA) play vital biological roles as energy sources, signaling molecules and key
building blocks of complex lipids in cell membranes. Modifications to FA structure and …

We describe the adaptation of a hybrid quadrupole linear ion trap− orbitrap mass
spectrometer to accommodate electron-transfer ion/ion reactions (ETD) for peptide and …

Five years ago, researchers discovered that electron-capture-dissociation-like fragmentation
could occur when peptide cations were reacted with radical anions. This technique, electron …