Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

CW Shields Iv, CD Reyes, GP López - Lab on a Chip, 2015 - pubs.rsc.org
Accurate and high throughput cell sorting is a critical enabling technology in molecular and
cellular biology, biotechnology, and medicine. While conventional methods can provide high …

The Poisson distribution and beyond: methods for microfluidic droplet production and single cell encapsulation

DJ Collins, A Neild, A DeMello, AQ Liu, Y Ai - Lab on a Chip, 2015 - pubs.rsc.org
There is a recognized and growing need for rapid and efficient cell assays, where the size of
microfluidic devices lend themselves to the manipulation of cellular populations down to the …

Nip the bubble in the bud: a guide to avoid gas nucleation in microfluidics

I Pereiro, AF Khartchenko, L Petrini, GV Kaigala - Lab on a Chip, 2019 - pubs.rsc.org
Gas bubbles are almost a routine occurrence encountered by researchers working in the
field of microfluidics. The spontaneous and unexpected nature of gas bubbles represents a …

Recent advances in the use of microfluidic technologies for single cell analysis

TW Murphy, Q Zhang, LB Naler, S Ma, C Lu - Analyst, 2018 - pubs.rsc.org
The inherent heterogeneity in cell populations has become of great interest and importance
as analytical techniques have improved over the past decades. With the advent of …

Highly focused high-frequency travelling surface acoustic waves (SAW) for rapid single-particle sorting

DJ Collins, A Neild, Y Ai - Lab on a Chip, 2016 - pubs.rsc.org
High-speed sorting is an essential process in a number of clinical and research applications,
where single cells, droplets and particles are segregated based on their properties in a …

Standing surface acoustic wave (SSAW) based multichannel cell sorting

X Ding, SCS Lin, MI Lapsley, S Li, X Guo, CY Chan… - Lab on a Chip, 2012 - pubs.rsc.org
We introduce a novel microfluidic device for cell sorting in continuous flow using tunable
standing surface acoustic waves. This method allows individual cells to be precisely directed …

Fluorescence activated cell sorting via a focused traveling surface acoustic beam

Z Ma, Y Zhou, DJ Collins, Y Ai - Lab on a Chip, 2017 - pubs.rsc.org
Fluorescence activated cell sorting (FACS) has become an essential technique widely
exploited in biological studies and clinical applications. However, current FACS systems are …

Focusing of sub-micrometer particles in microfluidic devices

T Zhang, ZY Hong, SY Tang, W Li, DW Inglis… - Lab on a Chip, 2020 - pubs.rsc.org
Sub-micrometer particles (0.10–1.0 μm) are of great significance to study, eg, microvesicles
and protein aggregates are targets for therapeutic intervention, and sub-micrometer …

Droplet microfluidics in (bio) chemical analysis

EY Basova, F Foret - Analyst, 2015 - pubs.rsc.org
Droplet microfluidics may soon change the paradigm of performing chemical analyses and
related instrumentation. It can improve not only the analysis scale, possibility for sensitivity …

Microfluidic: an innovative tool for efficient cell sorting

J Autebert, B Coudert, FC Bidard, JY Pierga… - Methods, 2012 - Elsevier
At first mostly dedicated to molecular analysis, microfluidic systems are rapidly expanding
their range of applications towards cell biology, thanks to their ability to control the …