Vanadium in diabetes: 100 years from Phase 0 to Phase I

KH Thompson, C Orvig - Journal of inorganic biochemistry, 2006 - Elsevier
A little over one hundred years ago, a vanadium-containing compound was assessed
clinically for use in treatment of human diabetic patients. The results were somewhat …

[HTML][HTML] Vanadium as potential therapeutic agent for COVID-19: A focus on its antiviral, antiinflamatory, and antihyperglycemic effects

S Semiz - Journal of Trace Elements in Medicine and Biology, 2022 - Elsevier
An increasing evidence suggests that vanadium compounds are novel potential drugs in the
treatment of diabetes, atherosclerosis, and cancer. Vanadium has also demonstrated …

Anti-diabetic effects of a series of vanadium dipicolinate complexes in rats with streptozotocin-induced diabetes

GR Willsky, LH Chi, M Godzala III, PJ Kostyniak… - Coordination Chemistry …, 2011 - Elsevier
The effects of oral treatment of rats with streptozotocin-induced diabetes with a range of
vanadium dipicolinate complexes (Vdipic) and derivatives are reviewed. Structure–reactivity …

Transport of therapeutic vanadium and ruthenium complexes by blood plasma components

J Costa Pessoa, I Tomaz - Current medicinal chemistry, 2010 - ingentaconnect.com
Low molecular weight and high molecular weight metal ion binders present in blood plasma
are shortly described. The binding of vanadium and ruthenium complexes by these …

Perspectives for vanadium in health issues

D Rehder - Future medicinal chemistry, 2016 - Taylor & Francis
Vanadium is omnipresent in trace amounts in the environment, in food and also in the
human body, where it might serve as a regulator for phosphate-dependent proteins …

Vanadium in biological systems and medicinal applications

D Rehder - Inorganica Chimica Acta, 2023 - Elsevier
The present review covers the environmental availability of vanadium and vanadium's
impact on the life sphere (geo-sphere, atmosphere, marine environments), as well as its …

[HTML][HTML] Interaction of amylin species with transition metals and membranes

M Alghrably, I Czaban, Ł Jaremko… - Journal of inorganic …, 2019 - Elsevier
Abstract Islet Amyloid Polypeptide (IAPP), also known as amylin, is a 37-amino-acid peptide
hormone that is secreted by pancreatic islet β-cells. Amylin is complementary to insulin in …

Biological activity of vanadium compounds

A Goc - Central European Journal of Biology, 2006 - Springer
Vanadium compounds are characterised by a broad spectrum of action in vivo and in vitro.
Their insulin-mimetic activity is manifested in their ability to normalize changes observed in …

Drug discovery and protein tyrosine phosphatases

MAT Blaskovich - Current medicinal chemistry, 2009 - ingentaconnect.com
Protein tyrosine phosphatases (PTPs) play a critical role in physiological signaling pathways
by controlling the level of tyrosine phosphorylation. The past decade has seen a vast …

Structural and redox requirements for the action of anti-diabetic vanadium compounds

Y Yoshikawa, H Sakurai, DC Crans, G Micera… - Dalton …, 2014 - pubs.rsc.org
This study presents the first systematic investigation of the anti-diabetic properties of non-
oxido VIV complexes. In particular, the insulin-mimetic activity of [VIV (taci) 2] 4+,[VIV (inoH …