NF-κB: at the borders of autoimmunity and inflammation
L Barnabei, E Laplantine, W Mbongo… - Frontiers in …, 2021 - frontiersin.org
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
Combinatorial, additive and dose-dependent drug–microbiome associations
SK Forslund, R Chakaroun… - Nature, 2021 - nature.com
During the transition from a healthy state to cardiometabolic disease, patients become
heavily medicated, which leads to an increasingly aberrant gut microbiome and serum …
heavily medicated, which leads to an increasingly aberrant gut microbiome and serum …
Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome
Over the past decade, great progress has been made in understanding the complexity of
adipose tissue biology and its role in metabolism. This includes new insights into the …
adipose tissue biology and its role in metabolism. This includes new insights into the …
Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation
A Irazoki, I Gordaliza-Alaguero, E Frank… - Nature …, 2023 - nature.com
Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial
DNA recognition by intracellular DNA sensors. However, the involvement of mitochondrial …
DNA recognition by intracellular DNA sensors. However, the involvement of mitochondrial …
Foundations of immunometabolism and implications for metabolic health and disease
GS Hotamisligil - Immunity, 2017 - cell.com
Highly ordered interactions between immune and metabolic responses are evolutionarily
conserved and paramount for tissue and organismal health. Disruption of these interactions …
conserved and paramount for tissue and organismal health. Disruption of these interactions …
Roles of NF-κB in cancer and inflammatory diseases and their therapeutic approaches
MH Park, JT Hong - Cells, 2016 - mdpi.com
Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various
biological processes, including immune response, inflammation, cell growth and survival …
biological processes, including immune response, inflammation, cell growth and survival …
Vanadium in biological action: chemical, pharmacological aspects, and metabolic implications in diabetes mellitus
S Treviño, A Díaz, E Sánchez-Lara… - Biological trace element …, 2019 - Springer
Vanadium compounds have been primarily investigated as potential therapeutic agents for
the treatment of various major health issues, including cancer, atherosclerosis, and …
the treatment of various major health issues, including cancer, atherosclerosis, and …
NF-kB and inflammatory cytokine signalling: role in skeletal muscle atrophy
A Thoma, AP Lightfoot - Muscle Atrophy, 2018 - Springer
Atrophy is a classical hallmark of an array of disorders that affect skeletal muscle, ranging
from inherited dystrophies, acquired inflammatory myopathies, ageing (sarcopenia) and …
from inherited dystrophies, acquired inflammatory myopathies, ageing (sarcopenia) and …
[HTML][HTML] Invited review: Inflammation during the transition to lactation: New adventures with an old flame
For dairy cattle, the first several weeks of lactation represent the highest-risk period in their
lives after their own neonatal period. Although more than 50% of cows during this period are …
lives after their own neonatal period. Although more than 50% of cows during this period are …