The past eighteen months have provided much progress in the cyclic nucleotide
phosphodiesterase (PDE) field. Six new phosphodiesterase genes have been discovered …

Erection is basically a spinal reflex that can be initiated by recruitment of penile afferents, but
also by visual, olfactory, and imaginary stimuli. The reflex involves both autonomic and …

Background Sildenafil is a potent inhibitor of cyclic guanosine monophosphate in the corpus
cavernosum and therefore increases the penile response to sexual stimulation. We …

Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE5), which has been
shown to be a clinically effective treatment for erectile dysfunction. Its action results from …

Nitric oxide (NO) induces the formation of intracellular cyclic guanosine monophosphate
(cGMP) by guanylate cyclase. Sildenafil, which selectively inhibits phosphodiesterase type 5 …

By real-time RT-PCR and Western blot analysis, we found that phosphodiesterase type 5
(PDE5) mRNA and protein abundance was several fold higher in human male than in …

Sildenafil, a selective inhibitor of phosphodiesterase type 5 (PDE5), is the first in a new class
of orally effective treatments for erectile dysfunction. During sexual stimulation, the …

Background & Aims: Sildenafil shows an intense and prolonged inhibitory effect on the
smooth muscle cells of the human corpus cavernosum by blocking phosphodiesterase type …

Background: Oesophageal clearance of acid reflux consists of an initial volume clearance
followed by neutralisation of the acidified mucosa by swallowed saliva (chemical clearance) …

The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and
regulates the intracellular level of cGMP in many tissues, including the smooth muscle of the …