Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions
SH Soderling, JA Beavo - Current opinion in cell biology, 2000 - Elsevier
The past eighteen months have provided much progress in the cyclic nucleotide
phosphodiesterase (PDE) field. Six new phosphodiesterase genes have been discovered …
phosphodiesterase (PDE) field. Six new phosphodiesterase genes have been discovered …
Pharmacology of penile erection
KE Andersson - Pharmacological reviews, 2001 - ASPET
Erection is basically a spinal reflex that can be initiated by recruitment of penile afferents, but
also by visual, olfactory, and imaginary stimuli. The reflex involves both autonomic and …
also by visual, olfactory, and imaginary stimuli. The reflex involves both autonomic and …
Oral sildenafil in the treatment of erectile dysfunction
I Goldstein, TF Lue, H Padma-Nathan… - … England Journal of …, 1998 - Mass Medical Soc
Background Sildenafil is a potent inhibitor of cyclic guanosine monophosphate in the corpus
cavernosum and therefore increases the penile response to sexual stimulation. We …
cavernosum and therefore increases the penile response to sexual stimulation. We …
Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae …
RM Wallis, JD Corbin, SH Francis, P Ellis - The American journal of …, 1999 - Elsevier
Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE5), which has been
shown to be a clinically effective treatment for erectile dysfunction. Its action results from …
shown to be a clinically effective treatment for erectile dysfunction. Its action results from …
Effects of sildenafil citrate on human hemodynamics
G Jackson, N Benjamin, N Jackson, MJ Allen - The American journal of …, 1999 - Elsevier
Nitric oxide (NO) induces the formation of intracellular cyclic guanosine monophosphate
(cGMP) by guanylate cyclase. Sildenafil, which selectively inhibits phosphodiesterase type 5 …
(cGMP) by guanylate cyclase. Sildenafil, which selectively inhibits phosphodiesterase type 5 …
Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa
By real-time RT-PCR and Western blot analysis, we found that phosphodiesterase type 5
(PDE5) mRNA and protein abundance was several fold higher in human male than in …
(PDE5) mRNA and protein abundance was several fold higher in human male than in …
Overall cardiovascular profile of sildenafil citrate
RM Zusman, A Morales, DB Glasser… - The American journal of …, 1999 - Elsevier
Sildenafil, a selective inhibitor of phosphodiesterase type 5 (PDE5), is the first in a new class
of orally effective treatments for erectile dysfunction. During sexual stimulation, the …
of orally effective treatments for erectile dysfunction. During sexual stimulation, the …
Effects of sildenafil on esophageal motility of patients with idiopathic achalasia
M Bortolotti, C Mari, C Lopilato, G Porrazzo, M Miglioli - Gastroenterology, 2000 - Elsevier
Background & Aims: Sildenafil shows an intense and prolonged inhibitory effect on the
smooth muscle cells of the human corpus cavernosum by blocking phosphodiesterase type …
smooth muscle cells of the human corpus cavernosum by blocking phosphodiesterase type …
Relevance of ineffective oesophageal motility during oesophageal acid clearance
M Simren, J Silny, R Holloway, J Tack, J Janssens… - Gut, 2003 - gut.bmj.com
Background: Oesophageal clearance of acid reflux consists of an initial volume clearance
followed by neutralisation of the acidified mucosa by swallowed saliva (chemical clearance) …
followed by neutralisation of the acidified mucosa by swallowed saliva (chemical clearance) …
Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds
IV Turko, SA Ballard, SH Francis, JD Corbin - Molecular Pharmacology, 1999 - ASPET
The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and
regulates the intracellular level of cGMP in many tissues, including the smooth muscle of the …
regulates the intracellular level of cGMP in many tissues, including the smooth muscle of the …