Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …

In contrast to adults, cardiac arrest in infants and children does not usually result from a
primary cardiac cause. More often it is the terminal result of progressive respiratory failure or …

Background Although therapeutic hypothermia reduces death or disability after neonatal
encephalopathy in high-income countries, its safety and efficacy in low-income and middle …

Importance Hypothermia initiated at less than 6 hours after birth reduces death or disability
for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our …

Background Therapeutic hypothermia is recommended for comatose adults after witnessed
out-of-hospital cardiac arrest, but data about this intervention in children are limited …

OBJECTIVE: Mild hypothermia after perinatal hypoxic-ischemic encephalopathy (HIE)
reduces neurologic sequelae without significant adverse effects, but studies are needed to …

Importance Hypothermia at 33.5° C for 72 hours for neonatal hypoxic ischemic
encephalopathy reduces death or disability to 44% to 55%; longer cooling and deeper …

Background Newborn admission temperature is a strong predictor of outcomes across all
gestations. Hypothermia immediately after birth remains a worldwide issue and, if …

Data from large randomized clinical trials indicate that therapeutic hypothermia, using either
selective head cooling or systemic cooling, is an effective therapy for neonatal …

Perinatal hypoxic-ischemic encephalopathy (HIE), a subset of neonatal encephalopathy, is
associated with high neonatal mortality and severe long-term neurologic morbidity. Until …