Metabolic syndrome (MS) is a chronic non‐infective syndrome characterised clinically by a
set of vascular risk factors that include insulin resistance, hypertension, abdominal obesity …

Many studies have reported that metabolic dysfunction is closely involved in the complex
mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which …

Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …

Background: Insulin resistance (IR) affects the development of type 2 diabetes mellitus
(T2DM), which is also influenced by accumulated fine particle air pollution [particulate matter …

Joint inflammation is present in the majority of OA patients and pro-inflammatory mediators,
such as IL-6, are actively involved in disease progression. Increased levels of IL-6 in serum …

Obesity and type 2 diabetes account for a considerable proportion of the global burden of
age-related metabolic diseases. In age-related metabolic diseases, tissue crosstalk and …

The immune checkpoint B7-H3 (CD276) is a member of the B7 family that has been studied
in the tumor microenvironment and immunotherapy, but its potential role in metabolism …

Background The low-grade chronic inflammation in diabetes plays an important role in
development of cardiovascular and renal complications. Sodium-glucose co-transporter-2 …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that leads to
progressive degeneration of motor neurons (MNs) and severe muscle atrophy without …

Frailty is a complex condition that emerges from dysregulation in multiple physiological
systems. Increasing evidence suggests the potential role of age-related energy …