The technological landscape and applications of single-cell multi-omics
Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …
simultaneously integrating various single-modality omics methods that profile the …
Targeted therapies for lung cancer patients with oncogenic driver molecular alterations
Lung cancer has traditionally been classified by histology. However, a greater
understanding of disease biology and the identification of oncogenic driver alterations has …
understanding of disease biology and the identification of oncogenic driver alterations has …
Lung adenocarcinoma promotion by air pollutants
A complete understanding of how exposure to environmental substances promotes cancer
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two …
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two …
[HTML][HTML] Premature mortality due to air pollution in European cities: a health impact assessment
S Khomenko, M Cirach, E Pereira-Barboza… - The Lancet Planetary …, 2021 - thelancet.com
Background Ambient air pollution is a major environmental cause of morbidity and mortality
worldwide. Cities are generally hotspots for air pollution and disease. However, the exact …
worldwide. Cities are generally hotspots for air pollution and disease. However, the exact …
Proteogenomic data and resources for pan-cancer analysis
Summary The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …
Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …
Cancer proteogenomics: current impact and future prospects
Genomic analyses in cancer have been enormously impactful, leading to the identification of
driver mutations and development of targeted therapies. But the functions of the vast majority …
driver mutations and development of targeted therapies. But the functions of the vast majority …
Genetic and non-genetic clonal diversity in cancer evolution
JRM Black, N McGranahan - Nature Reviews Cancer, 2021 - nature.com
The observation and analysis of intra-tumour heterogeneity (ITH), particularly in genomic
studies, has advanced our understanding of the evolutionary forces that shape cancer …
studies, has advanced our understanding of the evolutionary forces that shape cancer …
Antitumour immunity regulated by aberrant ERBB family signalling
S Kumagai, S Koyama, H Nishikawa - Nature Reviews Cancer, 2021 - nature.com
Aberrant signalling of ERBB family members plays an important role in tumorigenesis and in
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …
A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese population
Y Qu, J Feng, X Wu, L Bai, W Xu, L Zhu, Y Liu… - Nature …, 2022 - nature.com
Clear cell renal cell carcinoma (ccRCC) is a common and aggressive subtype of renal
cancer. Here we conduct a comprehensive proteogenomic analysis of 232 tumor and …
cancer. Here we conduct a comprehensive proteogenomic analysis of 232 tumor and …