Selective estrogen receptor modulators (SERMs) are a diverse group of nonsteroidal
compounds that function as agonists or antagonists for estrogen receptors (ERs) in a target …

Quinones represent a class of toxicological intermediates, which can create a variety of
hazardous effects in vivo including, acute cytotoxicity, immunotoxicity, and carcinogenesis …

The endocrine system is a major communication system in the body and is involved in
maintenance of the reproductive system, fetal development, growth, maturation, energy …

A wide variety of endogenous and exogenous alkylating agents attack DNA to preferentially
generate N7-alkylguanine (N7-alkylG) adducts. Studies of the effect of N7-alkylG lesions on …

Background Regarding the similar modulatory effects of both soy and tamoxifen on the
actions of estrogen which have previously reported, the aim of the present study was to …

In the present study, the effects of tamoxifen on pentylenetetrazole (PTZ)-induced repeated
seizures and hippocampal neuronal damage in ovariectomized rats were investigated …

Estrogen deficiency accelerates the development of several disorders including visceral
obesity and hepatic steatosis. The predisposing factors can be exacerbated by drugs that …

The effects of tamoxifen and soy on apoptosis of the hippocampus and dentate gyrus of
ovariectomized rats after repeated seizures were investigated. Female rats were divided …

ABSTRACT Cytochrome P450 (CYP450) system is a superfamily of hemecontaining
monooxygenase enzymes and represents one of the most extensively studied enzymatic …

乳腺癌已经成为危害女性健康的主要恶性肿瘤, 选择性雌激素受体调节剂作为治疗乳腺癌的有效
药物越来越受到人们的广泛关注. 笔者对选择性雌激素受体调节剂的研究现状进行综述.[关键词] …