Until around 1990, most multigene families were thought to be subject to concerted
evolution, in which all member genes of a family evolve as a unit in concert. However …

The chemical senses (smell and taste) have evolved complex repertoires of chemosensory
receptors—G-protein coupled receptors with a seven-transmembrane domain structure. In …

Understanding differences in the repertoire of orthologous gene pairs is vital for
interpretation of pharmacological and physiological experiments if conclusions are …

One key to animal survival is the detection and avoidance of potentially harmful compounds
by their bitter taste. Variable numbers of taste 2 receptor genes expressed in the gustatory …

Taste receptors function as one of the interfaces between internal and external milieus.
Taste receptors for sweet and umami (T1R [taste receptor, type 1]), bitter (T2R [taste …

Scope To avoid ingestion of potentially harmful substances, humans are equipped with
about 25 bitter taste receptor genes (TAS2R) expressed in oral taste cells. Humans exhibit …

Vertebrate Tas2r taste receptors bind to bitter compounds, which are typically poisonous, to
elicit bitter sensation to prevent the ingestion of toxins. Previous studies noted a marked …

In view of the importance of molecular sensing in the function of the gastrointestinal (GI)
tract, we assessed whether signal transduction proteins that mediate taste signaling are …

Taste reception is fundamental to diet selection in many animals. The genetic basis
underlying the evolution and diversity of taste reception, however, is not well understood …

Dorsal root ganglion (DRG) neurons detect sensory inputs and are crucial for pain
processing. They are often studied in vitro as dissociated cell cultures with the assumption …