Epidemiology of fracture risk with advancing age

KE Ensrud - Journals of Gerontology Series A: Biomedical …, 2013 - academic.oup.com
Bone loss and structural damage with advancing age lead to skeletal fragility as manifested
by low bone mass and deficits in bone geometry, microarchitecture, and material properties …

Skeletal aging

JG Sfeir, MT Drake, S Khosla, JN Farr - Mayo Clinic Proceedings, 2022 - Elsevier
Aging represents the single greatest risk factor for chronic diseases, including osteoporosis,
a skeletal fragility syndrome that increases fracture risk. Optimizing bone strength throughout …

[HTML][HTML] Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older

B Dawson-Hughes, SS Harris, EA Krall… - New England Journal …, 1997 - Mass Medical Soc
Background Inadequate dietary intake of calcium and vitamin D may contribute to the high
prevalence of osteoporosis among older persons. Methods We studied the effects of three …

Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial

DM Black, AV Schwartz, KE Ensrud, JA Cauley, S Levis… - Jama, 2006 - jamanetwork.com
ContextThe optimal duration of treatment of women with postmenopausal osteoporosis is
uncertain. ObjectiveTo compare the effects of discontinuing alendronate treatment after 5 …

Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial

JA Cauley, J Robbins, Z Chen, SR Cummings… - Jama, 2003 - jamanetwork.com
ContextIn the Women's Health Initiative trial of estrogen-plus-progestin therapy, women
assigned to active treatment had fewer fractures. ObjectiveTo test the hypothesis that the …

An update on the diagnosis and assessment of osteoporosis with densitometry

JA Kanis, CC Glüer… - Osteoporosis …, 2000 - Springer
In 1994 the WHO proposed guidelines for the diagnosis of osteoporosis based on
measurement of bone mineral density. They have been widely used for epidemiological …

Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study

MT Hannan, DT Felson… - Journal of Bone and …, 2000 - academic.oup.com
Few studies have evaluated risk factors for bone loss in elderly women and men. Thus, we
examined risk factors for 4‐year longitudinal change in bone mineral density (BMD) at the …

Clinical use of bone densitometry: scientific review

SR Cummings, D Bates, DM Black - Jama, 2002 - jamanetwork.com
ContextOsteoporosis causes substantial morbidity and costs $13.8 billion annually in the
United States. Measurement of bone mass by densitometry is a primary part of diagnosing …

Prevention of postmenopausal bone loss by a low‐magnitude, high‐frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety

C Rubin, R Recker, D Cullen, J Ryaby… - Journal of Bone and …, 2004 - academic.oup.com
Abstract A 1‐year prospective, randomized, double‐blind, and placebo‐controlled trial of 70
postmenopausal women demonstrated that brief periods (< 20 minutes) of a low‐level (0.2 …

Hip fracture in women without osteoporosis

SA Wainwright, LM Marshall, KE Ensrud… - The Journal of …, 2005 - academic.oup.com
The proportion of fractures that occur in women without osteoporosis has not been fully
described, and the characteristics of nonosteoporotic women who fracture are not well …