SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-
receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally …

There are many misconceptions surrounding the roles of protein phosphatases in the
regulation of signal transduction, perhaps the most damaging of which is the erroneous view …

Increased incidence of type 2 diabetes mellitus and obesity has elevated the medical need
for new agents to treat these disease states. Resistance to the hormones insulin and leptin …

Protein tyrosine phosphatase 1B (PTP1B) is an effective target for the treatment of both type
2 diabetes and obesity; however, targeting PTP1B for drug discovery is challenging because …

A critical early step in drug discovery is the screening of a chemical library. Typically,
promising compounds are identified in a primary screen and then more fully characterized in …

The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …

Conspectus Protein tyrosine phosphatases (PTPs) are essential signaling enzymes that,
together with protein tyrosine kinases, regulate tyrosine phosphorylation inside the cell …

Protein tyrosine phosphatases (PTPs) are signaling enzymes that control a diverse array of
cellular processes. Malfunction of PTP activity is associated with a number of human …

Protein tyrosine phosphatase 1B (PTP1B) and T‐cell protein tyrosine phosphatase (TC‐
PTP) play non‐redundant negative regulatory roles in T‐cell activation, tumor antigen …

Although initially viewed as housekeeping enzymes, research over the last 15 years has
revealed that the protein tyrosine phosphatases (PTPs) are critical regulators of tyrosine …