The inference of genetic ancestry plays an increasingly prominent role in clinical,
population, and forensic genetics studies. Several genotyping strategies and analytical …

There is mounting evidence of the value of clinical genome sequencing (cGS) in individuals
with suspected rare genetic disease (RGD), but cGS performance and impact on clinical …

Precision medicine pivots on the integration of patients' individual data including genetic
and genomic data, digital health measures, and social health factors, for the prevention …

Aim: To explore the pharmacogenetic differentiation across Latin American populations,
using the fixation index statistics (F ST). Materials & methods: F ST analyses were applied to …

This study shows that the distribution of CYP3A5 alleles (* 1,* 3,* 6 and* 7) and genotype-
predicted CYP3A5 phenotypes vary significantly across Latin American cohorts (Brazilians …

The current population of the Americas (~ 1 billion people) is highly heterogeneous as a
result of five centuries of admixture between three major parental populations, namely …

Admixture refers to the mixing of genetic ancestry from different populations. Admixture is
important for genomic medicine because it can affect how an individual responds to certain …

Carbamazepine triggers dermatologic hypersensitivity reactions, associated with specific
human leukocyte antigens (HLAs), especially HLA-B* 15: 02 and HLA-A* 31: 01. Previous …

Increasingly, the inference of genetic ancestry plays a prominent role in clinical, population
and forensic genetics studies. Over the last few decades, several genotyping strategies and …