Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Metallostasis in Alzheimer's disease
Abstract 2012 has been another year in which multiple large-scale clinical trials for
Alzheimer's disease (AD) have failed to meet their clinical endpoints. With the social and …
Alzheimer's disease (AD) have failed to meet their clinical endpoints. With the social and …
The chemistry of Alzheimer's disease
A Rauk - Chemical Society Reviews, 2009 - pubs.rsc.org
The chemistry of Alzheimer’s disease - Chemical Society Reviews (RSC Publishing) DOI:10.1039/B807980N
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B807980N …
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B807980N …
Copper and oxidative stress in the pathogenesis of Alzheimer's disease
G Eskici, PH Axelsen - Biochemistry, 2012 - ACS Publications
Copper is a redox-active metal with many important biological roles. Consequently, its
distribution and oxidation state are subject to stringent regulation. A large body of …
distribution and oxidation state are subject to stringent regulation. A large body of …
Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide
P Faller, C Hureau - Dalton transactions, 2009 - pubs.rsc.org
In the present perspective, we give a critical review on the coordination chemistry of the
metal ions copper and zinc to the amyloid-β (Aβ) peptide; such complexes have been linked …
metal ions copper and zinc to the amyloid-β (Aβ) peptide; such complexes have been linked …
[HTML][HTML] Polymorphism in Alzheimer Aβ amyloid organization reflects conformational selection in a rugged energy landscape
Amyloids can have normal biological functions. 1r3 However, amyloidogenic proteins can
also form unwanted oligomeric or polymeric aggregates when disturbed from their native …
also form unwanted oligomeric or polymeric aggregates when disturbed from their native …
[HTML][HTML] Multi-target directed donepezil-like ligands for Alzheimer's disease
M Unzeta, G Esteban, I Bolea, WA Fogel… - Frontiers in …, 2016 - frontiersin.org
HIGHLIGHTS ASS234 is a MTDL compound containing a moiety from Donepezil and the
propargyl group from the PF 9601N, a potent and selective MAO B inhibitor. This compound …
propargyl group from the PF 9601N, a potent and selective MAO B inhibitor. This compound …
[HTML][HTML] Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-β stability, oligomerization, and aggregation: amyloid-β destabilization promotes annular protofibril …
Abnormally high concentrations of Zn 2+, Cu 2+, and Fe 3+ are present along with amyloid-β
(Aβ) in the senile plaques in Alzheimer disease, where Al 3+ is also detected. Aβ …
(Aβ) in the senile plaques in Alzheimer disease, where Al 3+ is also detected. Aβ …
Copper (II) binding to amyloid-β fibrils of Alzheimer's disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Aβ oligomeric …
Cu2+ ions are found concentrated within senile plaques of Alzheimer's disease patients
directly bound to amyloid-β peptide (Aβ) and are linked to the neurotoxicity and self …
directly bound to amyloid-β peptide (Aβ) and are linked to the neurotoxicity and self …
Selenium, selenoprotein P, and Alzheimer's disease: is there a link?
N Solovyev, E Drobyshev, G Bjørklund… - Free Radical Biology …, 2018 - Elsevier
The essential trace element, selenium (Se), is crucial to the brain but it may be potentially
neurotoxic, depending on dosage and speciation; Se has been discussed for decades in …
neurotoxic, depending on dosage and speciation; Se has been discussed for decades in …