Alterations in protein structure may have profound effects on biological function. Analytical
techniques that permit characterization of proteins while maintaining their conformational …

Aptamers are single stranded DNA or RNA molecules that have been selected using in vitro
techniques to bind target molecules with high affinity and selectivity, rivaling antibodies in …

The study of drug–protein interactions can reveal the corresponding binding mechanisms,
providing valuable information for the early phase drug development and development of …

In the past two decades, CE has been used frequently for the measurement of apparent
binding/association constants. CE has numerous advantages, including short analysis …

Affinity capillary electrophoresis (ACE) is a separation technique that combines a
biologically-related binding agent with the separating power and efficiency of capillary …

Electrospray ionisation–mass spectrometry (ESI–MS) is used in a wide variety of fields to
examine the formation, stoichiometry and speciation of complexes involving metals and …

The significance and necessity of separating enantiomers in food, pharmaceuticals,
pesticides, and other samples remains constant and unrelenting. The successful chiral …

This review provides an overview of direct and indirect technologies to screen protein–
ligand interactions with mass spectrometry. These technologies have as a key feature the …

The review presents a comprehensive survey of recent developments of high‐performance
capillary electromigration methods, zone electrophoresis, ITP, IEF, affinity electrophoresis …

Biomolecules such as serum proteins can interact with drugs in the body and influence their
pharmaceutical effects. Specific and precise methods that analyze these interactions are …