Obesity: A perfect storm for carcinogenesis
BHL Harris, VM Macaulay, DA Harris… - Cancer and Metastasis …, 2022 - Springer
Obesity-related cancers account for 40% of the cancer cases observed in the USA and
obesity is overtaking smoking as the most widespread modifiable risk factor for …
obesity is overtaking smoking as the most widespread modifiable risk factor for …
Genetically adjusted PSA levels for prostate cancer screening
Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because
it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for …
it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for …
Benign SNPs in the Coding Region of TP53: Finding the Needles in a Haystack of Pathogenic Variants
T Soussi - Cancer Research, 2022 - AACR
With the recent explosion in high-throughput genotyping technology, the amount and quality
of SNP data have increased exponentially, facilitating the discovery of multiple uncommon …
of SNP data have increased exponentially, facilitating the discovery of multiple uncommon …
New role of fat-free mass in cancer risk linked with genetic predisposition
BHL Harris, M Di Giovannantonio, P Zhang… - Scientific Reports, 2024 - nature.com
Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass
and fat-free mass measurements from bioelectrical impedance may further clarify this …
and fat-free mass measurements from bioelectrical impedance may further clarify this …
Diversity of thought: public perceptions of genetic testing across ethnic groups in the UK
BHL Harris, C McCabe, H Shafique, S Lammy… - Journal of Human …, 2024 - nature.com
Genetic testing is becoming rapidly more accessible to the general populous either through
or outside healthcare systems. Few large-scale studies have been carried out to gauge …
or outside healthcare systems. Few large-scale studies have been carried out to gauge …
GSEA–SDBE: A gene selection method for breast cancer classification based on GSEA and analyzing differences in performance metrics
H Ai - PloS one, 2022 - journals.plos.org
Motivation Selecting the most relevant genes for sample classification is a common process
in gene expression studies. Moreover, determining the smallest set of relevant genes that …
in gene expression studies. Moreover, determining the smallest set of relevant genes that …
Leveraging genetic determinants of prostate-specific antigen levels towards improving prostate cancer screening
Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because
it increases overdiagnosis and overtreatment of clinically insignificant tumors. We …
it increases overdiagnosis and overtreatment of clinically insignificant tumors. We …
[HTML][HTML] Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk
Background: Nineteen genomic regions have been associated with high-grade serous
ovarian cancer (HGSOC). We used data from the Ovarian Cancer Association Consortium …
ovarian cancer (HGSOC). We used data from the Ovarian Cancer Association Consortium …
Exploring the frequency of a TP53 polyadenylation signal variant in tumor DNA from patients diagnosed with lung adenocarcinomas, sarcomas and uterine …
IA Vieira, GD Viola, EH Pezzi, TW Kowalski… - … and Molecular Biology, 2023 - SciELO Brasil
The TP53 3'UTR variant rs78378222 A> C has been detected in different tumor types as a
somatic alteration that reduces p53 expression through modification of polyadenylation and …
somatic alteration that reduces p53 expression through modification of polyadenylation and …
Height and risk of vitiligo: a nationwide cohort study
YB Lee, HS Kim - Journal of Clinical Medicine, 2021 - mdpi.com
Adult height is linked to the risk of several diseases, but its association with vitiligo has not
been established. This study aimed to investigate the relationship between adult height and …
been established. This study aimed to investigate the relationship between adult height and …