Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Background: Cancer cases have escalated by approximately 12% since 1900 and the
incidence rate has increased faster for females than males. The discovery of cisplatin in …

Breast cancer represents the most common diagnosed malignancy and the main leading
cause of tumor-related death among women worldwide. Therefore, several efforts have …

The EGFR-RAS-ERK pathway plays a key role in cancer development and progression.
However, the integral assembly of EGFR-RAS-ERK signaling complexes from the upstream …

Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein (HPIP) was
shown to play a role in cancer development and progression. However, the role of HPIP in …

Osteoarthritis (OA) has been recognized as the most common chronic age-related disease.
Cartilage degeneration influences OA therapy. Here we report that hematopoietic pre-B cell …

Purpose Hematopoietic PBX interacting protein (HPIP), a scaffold protein, is known to
regulate the proliferation, migration and invasion in different cancer cell types. The aim of …

While cancer cells rewire metabolic pathways to sustain growth and survival under
metabolic stress in solid tumors, the molecular mechanisms underlying these processes …

While phenotypic plasticity is a critical factor contributing to tumor heterogeneity, molecular
mechanisms underlying this process are largely unknown. Here we report that breast cancer …