Consistent age-dependent declines in human semen quality: a systematic review and meta-analysis

SL Johnson, J Dunleavy, NJ Gemmell… - Ageing research …, 2015 - Elsevier
Reduced fertility typically occurs among women in their late 30s, but increasing evidence
indicates that advanced paternal age is associated with changes in reproduction as well …

Oxidative stress and male infertility—a clinical perspective

K Tremellen - Human reproduction update, 2008 - academic.oup.com
Oxidative stress occurs when the production of potentially destructive reactive oxygen
species (ROS) exceeds the bodies own natural antioxidant defenses, resulting in cellular …

Advanced cell culture techniques for cancer drug discovery

CJ Lovitt, TB Shelper, VM Avery - Biology, 2014 - mdpi.com
Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

[HTML][HTML] Association between socio-psycho-behavioral factors and male semen quality: systematic review and meta-analyses

Y Li, H Lin, Y Li, J Cao - Fertility and sterility, 2011 - Elsevier
OBJECTIVE: To identify the factors associated with male semen quality from many socio-
psycho-behavioral factors. DESIGN: Medline/PubMed, EMBASE, and CNKI were searched …

Paternal age and reproduction

GA Sartorius, E Nieschlag - Human reproduction update, 2010 - academic.oup.com
BACKGROUND Due to various sociological factors, couples in developed countries are
increasingly delaying childbearing. Besides ethical, economical and sociological issues, this …

[HTML][HTML] Fertility and the aging male

ID Harris, C Fronczak, L Roth, RB Meacham - Reviews in urology, 2011 - ncbi.nlm.nih.gov
Abstract In the United States since 1980, the birth rate in women aged> 35 years has
increased by nearly 60%, whereas the birth rate for women aged 20 to 34 years has …

[HTML][HTML] Age thresholds for changes in semen parameters in men

BA Stone, A Alex, LB Werlin, RP Marrs - Fertility and sterility, 2013 - Elsevier
Objective To determine whether age thresholds for elements of semen quality exist. Design
Retrospective analysis (covariance and point-change analysis) of results of 4,822 semen …

Oxidative stress and medical antioxidant treatment in male infertility

FM Lanzafame, S La Vignera, E Vicari… - Reproductive …, 2009 - Elsevier
Oxidative stress (OS) has been recognized as one of the most important cause of male
infertility. Despite the antioxidant activity of seminal plasma, epididymis and spermatozoa …

[HTML][HTML] Semen characteristics and sperm DNA fragmentation in infertile men with low and high levels of seminal reactive oxygen species

R Mahfouz, R Sharma, A Thiyagarajan, V Kale… - Fertility and sterility, 2010 - Elsevier
OBJECTIVE: To examine sperm motility, total antioxidant level (TAC), DNA fragmentation,
and medical history in infertile men with high seminal high reactive oxygen species (ROS) …

Hallmarks of testicular aging: the challenge of anti-inflammatory and antioxidant therapies using natural and/or pharmacological compounds to improve the …

ME Matzkin, RS Calandra, SP Rossi, A Bartke… - Cells, 2021 - mdpi.com
The evolutionary theory of aging supports a trade-off relationship between reproduction and
aging. Aging of the male reproductive system primarily affects the testes, leading to a …