Plant sphingolipids: decoding the enigma of the Sphinx

MO Pata, YA Hannun, CKY Ng - New Phytologist, 2010 - Wiley Online Library
Sphingolipids are a ubiquitous class of lipids present in a variety of organisms including
eukaryotes and bacteria. In the last two decades, research has focused on characterizing …

Pseudomonas exotoxin A: from virulence factor to anti-cancer agent

P Wolf, U Elsässer-Beile - International Journal of Medical Microbiology, 2009 - Elsevier
The pathogenic bacterium Pseudomonas aeruginosa has the ability to cause severe acute
and chronic infections in humans. Pseudomonas exotoxin A (PE) is the most toxic virulence …

Deregulation of sphingolipid metabolism in Alzheimer's disease

X He, Y Huang, B Li, CX Gong, EH Schuchman - Neurobiology of aging, 2010 - Elsevier
Abnormal sphingolipid metabolism has been previously reported in Alzheimer's disease
(AD). To extend these findings, several sphingolipids and sphingolipid hydrolases were …

Molecular Healing of Polymeric Materials, Coatings, Plastics, Elastomers, Composites, Laminates, Adhesives, and Sealants by Active Enzymes

CS McDaniel, ME Wales, J Rawlins, P Cipi… - US Patent App. 12 …, 2010 - Google Patents
2010-04-30 Assigned to REACTIVE SURFACES, LTD. reassignment REACTIVE
SURFACES, LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases

D Canals, DM Perry, RW Jenkins… - British journal of …, 2011 - Wiley Online Library
Sphingolipids represent a class of diverse bioactive lipid molecules that are increasingly
appreciated as key modulators of diverse physiologic and pathophysiologic processes that …

[HTML][HTML] Molecular cloning and characterization of a human mitochondrial ceramidase

S El Bawab, P Roddy, T Qian, A Bielawska… - Journal of Biological …, 2000 - ASBMB
We have recently purified a rat brain membrane-bound nonlysosomal ceramidase (El
Bawab, S., Bielawska, A., and YA Hannun (1999) J. Biol. Chem. 274, 27948–27955). Using …

[HTML][HTML] Inhibitors of sphingolipid metabolism enzymes

A Delgado, J Casas, A Llebaria, JL Abad… - Biochimica et Biophysica …, 2006 - Elsevier
Sphingolipids are a family of lipids that play essential roles both as structural cell membrane
components and in cell signalling. The cellular contents of the various sphingolipid species …

Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space

M Tani, M Ito, Y Igarashi - Cellular signalling, 2007 - Elsevier
Sphingolipid metabolites, ceramide, sphingosine, and sphingosine 1-phosphate, have
emerged as a new class of lipid biomodulators of various cell functions. These metabolites …

[HTML][HTML] Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids

M Kono, JL Dreier, JM Ellis, ML Allende… - Journal of Biological …, 2006 - ASBMB
Complex sphingolipids are abundant as eukaryotic cell membrane components, whereas
their metabolites, in particular ceramide, sphingosine, and sphingosine 1-phosphate, are …

Polymeric Coatings Incorporating Bioactive Enzymes for Cleaning a Surface

M Wales, CS McDaniel - US Patent App. 13/069,864, 2011 - Google Patents
C09D—COATING COMPOSITIONS, eg PAINTS, VARNISHES OR LACQUERS; FILLING
PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; …