Integrons: past, present, and future

MR Gillings - Microbiology and molecular biology reviews, 2014 - Am Soc Microbiol
Integrons are versatile gene acquisition systems commonly found in bacterial genomes.
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …

Dissemination of antibiotic resistance genes (ARGs) via integrons in Escherichia coli: a risk to human health

S Zhang, M Abbas, MU Rehman, Y Huang, R Zhou… - Environmental …, 2020 - Elsevier
With the induction of various emerging environmental contaminants such as antibiotic
resistance genes (ARGs), environment is considered as a key indicator for the spread of …

SOS, the formidable strategy of bacteria against aggressions

Z Baharoglu, D Mazel - FEMS microbiology reviews, 2014 - academic.oup.com
The presence of an abnormal amount of single-stranded DNA in the bacterial cell constitutes
a genotoxic alarm signal that induces the SOS response, a broad regulatory network found …

Inactivation of antibiotics and the dissemination of resistance genes

J Davies - Science, 1994 - science.org
The emergence of multidrug-resistant bacteria is a phenomenon of concern to the clinician
and the pharmaceutical industry, as it is the major cause of failure in the treatment of …

Integrons

G Cambray, AM Guerout, D Mazel - Annual review of genetics, 2010 - annualreviews.org
Integrons are genetic elements able to acquire and rearrange open reading frames (ORFs)
embedded in gene cassette units and convert them to functional genes by ensuring their …

Gene cassettes and cassette arrays in mobile resistance integrons

SR Partridge, G Tsafnat, E Coiera… - FEMS microbiology …, 2009 - academic.oup.com
Gene cassettes are small mobile elements, consisting of little more than a single gene and
recombination site, which are captured by larger elements called integrons. Several …

Pathogenicity islands and the evolution of microbes

J Hacker, JB Kaper - Annual Reviews in Microbiology, 2000 - annualreviews.org
▪ Abstract Virulence factors of pathogenic bacteria (adhesins, toxins, invasins, protein
secretion systems, iron uptake systems, and others) may be encoded by particular regions of …

PCR mapping of integrons reveals several novel combinations of resistance genes

C Levesque, L Piche, C Larose… - Antimicrobial agents and …, 1995 - Am Soc Microbiol
The integron is a new type of mobile element which has evolved by a site-specific
recombinational mechanism. Integrons consist of two conserved segments of DNA …

Mobile gene cassettes and integrons: capture and spread of genes by site‐specific recombination

RM Hall, CM Collis - Molecular microbiology, 1995 - Wiley Online Library
An integron is a genetic unit that includes the determinants of the components of a site‐
specific recombination system capable of capturing and mobilizing genes that are contained …

Transposon Tn21, Flagship of the Floating Genome

CA Liebert, RM Hall, AO Summers - Microbiology and molecular …, 1999 - Am Soc Microbiol
The transposon Tn21 and a group of closely related transposons (the Tn21 family) are
involved in the global dissemination of antibiotic resistance determinants in gram-negative …