Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson's
disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an …

A full understanding of Parkinson's Disease etiopathogenesis and of the causes of the
preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A …

Significant advances have been made uncovering the factors that render neurons
vulnerable in Parkinson's disease (PD). However, the critical pathogenic events leading to …

Background: Studies investigating the impact of a variety of inflammatory stimuli on the brain
and behavior have reported evidence that inflammation and release of inflammatory …

Parkinson disease (PD) is a chronic, progressive neurological disease that is associated
with a loss of dopaminergic neurons in the substantia nigra pars compacta of the brain. The …

In Parkinson's disease (PD) there is a selective degeneration of neuromelanin-containing
neurons, especially substantia nigra dopaminergic neurons. In humans, neuromelanin …

Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and
misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The …

Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …

Motivational and motor deficits are common in patients with depression and other psychiatric
disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in …

MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal
differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis …