Botulinum and tetanus neurotoxins
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins
known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as …
known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as …
Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update
Tetanus and botulinum neurotoxins cause the neuroparalytic syndromes of tetanus and
botulism, respectively, by delivering inside different types of neurons, metalloproteases …
botulism, respectively, by delivering inside different types of neurons, metalloproteases …
Bacterial signaling to the nervous system through toxins and metabolites
NJ Yang, IM Chiu - Journal of molecular biology, 2017 - Elsevier
Mammalian hosts interface intimately with commensal and pathogenic bacteria. It is
increasingly clear that molecular interactions between the nervous system and microbes …
increasingly clear that molecular interactions between the nervous system and microbes …
Synaptic vesicle glycoprotein 2A: features and functions
In recent years, the field of neuroimaging dramatically moved forward by means of the
expeditious development of specific radioligands of novel targets. Among these targets, the …
expeditious development of specific radioligands of novel targets. Among these targets, the …
Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties
The fusion pore is the first crucial intermediate formed during exocytosis, yet little is known
about the mechanisms that determine the size and kinetic properties of these transient …
about the mechanisms that determine the size and kinetic properties of these transient …
Botulinum neurotoxins A and E undergo retrograde axonal transport in primary motor neurons
The striking differences between the clinical symptoms of tetanus and botulism have been
ascribed to the different fate of the parental neurotoxins once internalised in motor neurons …
ascribed to the different fate of the parental neurotoxins once internalised in motor neurons …
Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A
A Yamagata, K Ito, T Suzuki, N Dohmae… - Nature …, 2024 - nature.com
More than one percent of people have epilepsy worldwide. Levetiracetam (LEV) is a
successful new-generation antiepileptic drug (AED), and its derivative, brivaracetam (BRV) …
successful new-generation antiepileptic drug (AED), and its derivative, brivaracetam (BRV) …
The synaptic vesicle glycoprotein 2: structure, function, and disease relevance
The synaptic vesicle glycoprotein 2 (SV2) family is comprised of three paralogues: SV2A,
SV2B, and SV2C. In vertebrates, SV2s are 12-transmembrane proteins present on every …
SV2B, and SV2C. In vertebrates, SV2s are 12-transmembrane proteins present on every …
Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
Abstract Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and
paradoxically also a promising therapeutic agent. Here we determined the co-crystal …
paradoxically also a promising therapeutic agent. Here we determined the co-crystal …
Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism
The botulinum neurotoxins (BoNTs) are di-chain bacterial proteins responsible for the
paralytic disease botulism. Following binding to the plasma membrane of cholinergic motor …
paralytic disease botulism. Following binding to the plasma membrane of cholinergic motor …