Background Disorders of the mitochondrial respiratory chain are heterogeneous in their
symptoms and underlying genetics. Simple links between candidate mutations and …

DNA methylation is an essential mechanism controlling gene expression during
differentiation and development. We investigated the epigenetic regulation of the nuclear …

Undifferentiated mouse embryonic stem cells (ESCs) possess low numbers of mitochondrial
DNA (mtDNA), which encodes key subunits associated with the generation of ATP through …

Mitochondrial DNA haplotypes are associated with various phenotypes, such as altered
susceptibility to disease, environmental adaptations, and aging. Accumulating evidence …

In this study, we deep-sequenced the mtDNA of human embryonic and induced pluripotent
stem cells (hESCs and hiPSCs) and their source cells and found that the majority of variants …

We generated cattle embryos using mitochondrial supplementation and somatic cell nuclear
transfer (SCNT), named miNT, to determine how additional mitochondrial DNA (mtDNA) …

Reprogramming of human fibroblasts into induced pluripotent stem cells (iPSCs) leads to
mitochondrial rejuvenation, making iPSCs a candidate model to study the mitochondrial …

Mitochondrial DNA (mtDNA) encodes proteins for the electron transport chain which
produces the vast majority of cellular energy. MtDNA has its own replication and …

The vast majority of cellular energy is generated through the process of oxidative
phosphorylation, which takes place in the electron transport chain in the mitochondria. The …

Besides being crucial for cellular bioenergetics, mitochondria are key players in many
pathophysiological processes: from cell death to autophagy, immunity. 1 In cancer, not only …