Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of
three subunits—troponin I, T, and C, and it plays a crucial role in muscle activity, connecting …

More than 350 individual MYPBC3 mutations have been identified in patients with inherited
hypertrophic cardiomyopathy (HCM), thus representing 40–50% of all HCM mutations …

The giant sarcomeric protein titin contains a protein kinase domain (TK) ideally positioned to
sense mechanical load. We identified a signaling complex where TK interacts with the zinc …

A rapid increase in the synthesis of lipid-derived second messengers with subsequent
activation of protein phosphorylation cascades has emerged as one of the fundamental …

During the past 5 years there has been an increasing body of literature describing the roles
cardiac myosin binding protein C (cMyBP-C) phosphorylation play in regulating cardiac …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

Rationale: High-myofilament Ca2+ sensitivity has been proposed as a trigger of disease
pathogenesis in familial hypertrophic cardiomyopathy (HCM) on the basis of in vitro and …

In response to acute and chronic stresses, the heart frequently undergoes a remodeling
process that is accompanied by myocyte hypertrophy, impaired contractility, and pump …

Oxidative stress accompanies a wide spectrum of clinically important cardiac disorders,
including ischemia/reperfusion, diabetes mellitus, and hypertensive heart disease. Although …

The adult heart responds to biomechanical stress and neurohormonal signaling by
hypertrophic growth, accompanied by fibrosis, diminished pump function, and activation of a …