The complement system comprises several fluid-phase and membrane-associated proteins.
Under physiological conditions, activation of the fluid-phase components of complement is …

The immunogenicity of polysaccharides as human vaccines was enhanced by coupling to
protein carriers. Conjugation transformed the T cell-independent polysaccharide vaccines of …

Meningococcal disease describes the spectrum of infections caused by Neisseria
meningiditis, including meningitdis, bacteremia, and bacteremic pneumonia. Two …

This report updates the 2004 recommendations by the Advisory Committee on Immunization
Practices (ACIP) regarding the use of influenza vaccine and antiviral agents (CDC …

A major diagnostic intervention in the consideration of many patients suspected to have
primary immunodeficiency diseases (PIDDs) is the application and interpretation of …

Despite considerable advances in the understanding of the pathogenesis of meningococcal
disease, this infection remains a major cause of morbidity and mortality globally. The role of …

The antibody data supporting the use of meningococcal serogroup C conjugate (MCC)
vaccines in the United Kingdom were generated by serum bactericidal assay (SBA) using …

The human bacterial pathogen Neisseria meningitidis remains a serious worldwide health
threat, but progress is being made toward the control of meningococcal infections. This …

Streptococcus pneumoniae is a major cause of morbidity and mortality in children less than
5 years of age. Prevention of pneumococcal disease and death in children in the developing …

Neisseria meningitidis is a major cause of bacterial meningitis and sepsis. Polysaccharide–
protein conjugate vaccines for prevention of group C disease have been licensed in Europe …