Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal
transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable …

After stroke the central nervous system reveals a spectrum of intrinsic capacities to react as a
highly dynamic system which can change the properties of its circuits, form new contacts …

Microdialysis enables the chemistry of the extracellular interstitial space to be monitored.
Use of this technique in patients with acute brain injury has increased our understanding of …

Methods: The Critical Care Continuous EEG Task Force of the American Clinical
Neurophysiology Society developed expert consensus recommendations on the use of …

Importance Periodic discharges (PDs) that do not meet seizure criteria, also termed theictal
interictal continuum, are pervasive on electroencephalographic (EEG) recordings after acute …

Objective Restoring the circulation is the primary goal in emergency treatment of cerebral
ischemia. However, better understanding of how the brain responds to energy depletion …

Objective Seizures have been implicated as a cause of secondary brain injury, but the
systemic and cerebral physiologic effects of seizures after acute brain injury are poorly …

Background and Purpose—To identify a minimally acceptable cerebral perfusion pressure
threshold above which the risks of brain tissue hypoxia (BTH) and oxidative metabolic crisis …

Introduction There is a substantial amount of evidence from animal models that early brain
injury (EBI) may play an important role for secondary brain injury after aneurysmal …

Background: Targeting a cerebral perfusion pressure optimal for cerebral autoregulation
(CPPopt) has been gaining more attention to prevent secondary damage after acute …