Advances in copper complexes as anticancer agents

C Santini, M Pellei, V Gandin, M Porchia… - Chemical …, 2014 - ACS Publications
Medicinal inorganic chemistry offers additional opportunities for the design of therapeutic
agents not accessible to organic compounds. 1− 3 The wide range of coordination numbers …

Oxidative stress in apoptosis and cancer: an update

JM Matés, JA Segura, FJ Alonso, J Márquez - Archives of toxicology, 2012 - Springer
The oxygen paradox tells us that oxygen is both necessary for aerobic life and toxic to all life
forms. Reactive oxygen species (ROS) touch every biological and medical discipline …

Effect of N (4)-phenyl substitution in 2-oxo-1, 2-dihydroquinoline-3-carbaldehyde semicarbazones on the structure, DNA/protein interaction, and antioxidative and …

D Senthil Raja, NSP Bhuvanesh… - Inorganic Chemistry, 2011 - ACS Publications
A new ligand, 2-oxo-1, 2-dihydroquinoline-3-carbaldehyde semicarbazone (OQsc-H)(1);, its
N (4)-phenyl derivative (OQsc-Ph)(2); and their corresponding copper (II) complexes [CuCl2 …

BSA binding and antimicrobial studies of branched polyethyleneimine–copper (II) bipyridine/phenanthroline complexes

G Vignesh, S Arunachalam, S Vignesh… - Spectrochimica Acta Part …, 2012 - Elsevier
The interaction of two water soluble branched polyethyleneimine–copper (II) complexes
containing bipyridine/phenanthroline with bovine serum albumin (BSA) was studied by, UV …

Redox-implications associated with the formation of complexes between copper ions and reduced or oxidized glutathione

ME Aliaga, C López-Alarcón, R Bridi… - Journal of inorganic …, 2016 - Elsevier
Binding of copper by reduced glutathione (GSH) is generally seen as a mechanism to lower,
if not abolish, the otherwise high electrophilicity and redox activity of its free ions. In recent …

Synthesis, spectroscopic characterisation, DNA cleavage, superoxidase dismutase activity and antibacterial properties of some transition metal complexes of a novel …

LP Nitha, R Aswathy, NE Mathews… - Spectrochimica Acta Part …, 2014 - Elsevier
Complexes of manganese (II), cobalt (II), nickel (II), copper (II) and zinc (II) with a Schiff base,
formed by the condensation of isatin with 2-aminopyrimidine have been synthesised and …

SOD activity of new copper II complexes with ligands derived from pyridoxal and toxicity in Caenorhabditis elegans

JD Siqueira, SF de Pellegrin, SS Dos Santos… - Journal of Inorganic …, 2020 - Elsevier
This work presents the synthesis, characterization of copper (II) complexes (C1-C6) and the
potential of these compounds to mimic the catalytic activity of the enzyme superoxide …

The functional role of MnSOD as a biomarker of human diseases and therapeutic potential of a new isoform of a human recombinant MnSOD

A Borrelli, A Schiattarella, P Bonelli… - BioMed research …, 2014 - Wiley Online Library
Reactive oxygen species (ROS) are generated as a consequence of metabolic reactions in
the mitochondria of eukaryotic cells. This work describes the role of the manganese …

Synthesis, structure and superoxide dismutase-like activity of two mixed-ligand Cu (II) complexes with N, N′-bis (2-pyridylmethyl) amantadine

YH Zhou, XW Liu, LQ Chen, SQ Wang, Y Cheng - Polyhedron, 2016 - Elsevier
Two mixed-ligand Cu (II) complexes,[Cu (L 1)(L 2)](ClO 4) 2· H 2 O (1) and [Cu (L 1)(L
3)](ClO 4) 2· H 2 O· CH 3 OH (2)(L 1= N, N′-bis (2-pyridylmethyl) amantadine, L 2= 5, 5 …

Copper complexes of bioactive ligands with superoxide dismutase activity

H Khalid, M Hanif, M Ali Hashmi… - Mini reviews in …, 2013 - ingentaconnect.com
Free radicals or reactive oxygen species (ROS) are highly toxic and their damaging effects
result in a variety of detrimental health issues such as neurodegenerative, cardiovascular …