Proper progression throughout the cell division cycle depends on the expression level of a
family of proteins known as cyclins, and the subsequent activation of cyclin-dependent …

Newly described classes of G, cyclins and their cyclindependent kinases (cdks) are proving
to be integrators of growth factor-mediated signals that drive the cell cycle. Growth factors act …

A cascade of events is triggered upon the addition of growth factor to quiescent mammalian
cells, which ultimately restarts proliferation by inducing the transition from G0/G1 to S-phase …

Cyclin degradation is the key step governing exit from mitosis and progress into the next cell
cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a …

Cyclins play a fundamental role in regulating cell cycle events in all eukaryotic cells. The
human cyclin A gene was identified as the site of integration of hepatitis B virus in a …

The retinoblastoma protein (pRb) acts to constrain the G1-S transition in mammalian cells.
Phosphorylation of pRb in G1 inactivates its growth-inhibitory function, allowing for cell cycle …

The proteolysis of key regulatory proteins is thought to control progress through mitosis.
Here we analyse cyclin B1 degradation in real time and find that it begins as soon as the last …

Cyclin A is particularly interesting among the cyclin family because it can activate two
different cyclin-dependent kinases (CDKs) and functions in both S phase and mitosis. An …

WE have previously identified a candidate oncogene (PRAD1 or D11S287E) on
chromosome Ilql3 which is clonally rearranged with the parathyroid hormone locus in a …

D-type cyclin-dependent kinase activities have not so far been detected in mammalian cells.
Lysis of rodent fibroblasts, mouse macrophages, or myeloid cells with Tween 20 followed by …