Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an
important contributor to the pathobiology of atherosclerotic cardiovascular disease …

Over the past several decades, there have been substantial advances in our knowledge of
the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to …

Background: Coronary atherosclerosis may develop at an early age and remain latent for
many years. Objective: To define characteristics of subclinical coronary atherosclerosis …

Rationale: Neutrophils likely contribute to the thrombotic complications of human
atheromata. In particular, neutrophil extracellular traps (NETs) could exacerbate local …

Aims Superficial erosion of atheromata causes many acute coronary syndromes, but arises
from unknown mechanisms. This study tested the hypothesis that Toll-like receptor-2 (TLR2) …

Aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising
therapeutic target for the treatment of hypercholesterolaemia and atherosclerosis. PCSK9 …

Programmed cell death (PCD) has been a major area of constantly growing interest over the
last three decades. Originally, apoptosis was considered the only mechanistic pathway for …

Rationale: Superficial erosion currently causes up to a third of acute coronary syndromes;
yet, we lack understanding of its mechanisms. Thrombi because of superficial intimal …

Background and aims In one-third of patients with acute coronary syndrome (ACS),
thrombosis occurs despite an intact fibrous cap (IFC)(IFC–ACS,'plaque erosion'). Recent …

Plaques vulnerable to rupture are characterized by a thin and stiff fibrous cap overlaying a
soft lipid-rich necrotic core. The ability to measure local plaque stiffness directly to quantify …