From basics to clinical: a comprehensive review on spinal cord injury
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …
individuals each year. Over the past decades an enormous progress has been made in our …
Role and therapeutic potential of VEGF in the nervous system
C Ruiz de Almodovar, D Lambrechts… - Physiological …, 2009 - journals.physiology.org
The development of the nervous and vascular systems constitutes primary events in the
evolution of the animal kingdom; the former provides electrical stimuli and coordination …
evolution of the animal kingdom; the former provides electrical stimuli and coordination …
Exosomal OTULIN from M2 macrophages promotes the recovery of spinal cord injuries via stimulating Wnt/β-catenin pathway-mediated vascular regeneration
Z Luo, W Peng, Y Xu, Y Xie, Y Liu, H Lu, Y Cao, J Hu - Acta biomaterialia, 2021 - Elsevier
Vascularization following spinal cord injury (SCI) provides trophic support for rebuilding up
and maintaining the homeostasis of neuronal networks, and the promotion of angiogenesis …
and maintaining the homeostasis of neuronal networks, and the promotion of angiogenesis …
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
D Lambrechts, E Storkebaum, M Morimoto… - Nature …, 2003 - nature.com
Amyotrophic lateral sclerosis (ALS) is an incurable degenerative disorder of motoneurons.
We recently reported that reduced expression of Vegfa causes ALS-like motoneuron …
We recently reported that reduced expression of Vegfa causes ALS-like motoneuron …
VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection
Both blood vessels and nerves are guided to their target. Vascular endothelial growth factor
(VEGF) A is a key signal in the induction of vessel growth (a process termed angiogenesis) …
(VEGF) A is a key signal in the induction of vessel growth (a process termed angiogenesis) …
VEGF in the nervous system
JM Rosenstein, JM Krum, C Ruhrberg - Organogenesis, 2010 - Taylor & Francis
Vascular endothelial growth factor (VEGF, VEGFA) is critical for blood vessel growth in the
developing and adult nervous system of vertebrates. Several recent studies demonstrate …
developing and adult nervous system of vertebrates. Several recent studies demonstrate …
VEGF: a critical player in neurodegeneration
E Storkebaum, P Carmeliet - The Journal of clinical …, 2004 - Am Soc Clin Investig
VEGF is a prototype angiogenic factor, but recent evidence indicates that this growth factor
also has direct effects on neural cells. Abnormal regulation of VEGF expression has now …
also has direct effects on neural cells. Abnormal regulation of VEGF expression has now …
Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations
Bone marrow stromal cells (MSC) are non-hematopoietic support cells that can be easily
derived from bone marrow aspirates. Human MSC are clinically attractive because they can …
derived from bone marrow aspirates. Human MSC are clinically attractive because they can …
New roles for VEGF in nervous tissue—beyond blood vessels
JM Rosenstein, JM Krum - Experimental neurology, 2004 - Elsevier
Vascular endothelial growth factor (VEGF) is a secreted dimeric polypeptide that until
recently has been believed to be a specific mitogen for endothelial cells subserving …
recently has been believed to be a specific mitogen for endothelial cells subserving …
Neuroprotective role of vascular endothelial growth factor: signalling mechanisms, biological function, and therapeutic potential
I Zachary - Neurosignals, 2005 - karger.com
Vascular endothelial growth factor (VEGF or VEGF-A) and its receptors play essential roles
in the formation of blood vessels during embryogenesis and in disease. Most biological …
in the formation of blood vessels during embryogenesis and in disease. Most biological …