▪ Abstract Apoptosis, a physiological process for killing cells, is critical for the normal
development and function of multicellular organisms. Abnormalities in cell death control can …

▪ Abstract Successful viral replication requires not only the efficient production and spread of
progeny, but also evasion of host defense mechanisms that limit replication by killing …

The baculovirus P35 protein functions to prevent apoptotic death of infected cells. We have
expressed P35 in the developing embryo and eye of the fly Drosophila melanogaster. P35 …

The adaptation of adenoviruses as gene delivery tools has resulted in the development of
high-capacity adenoviral vectors (HC-AdVs), also known, helper-dependent or “gutless” …

Adenovirus (Ad) infection is concluded by assembly of virions in the cell nucleus followed by
lysis of cells by an unknown mechanism. We have described an Ad nuclear membrane …

Apoptosis is the process whereby individual cells of multicellular organisms undergo
systematic self-destruction in response to a wide variety of stimuli. Apoptosis is a genetically …

Many viruses have as part of their arsenal the ability to modulate the apoptotic pathways of
the host. It is counter-intuitive that such simple organisms would be efficient at regulating this …

ADENOVIRUSES WERE FIRST DISCOVERED half a century ago by Rowe and colleagues,
who were trying to culture adenoid tissue in the laboratory (Rowe et al., 1953). Since that …

The adenovirus E1A and E1B proteins are required for transformation of primary rodent
cells. When expressed in the absence of the 19,000-dalton (19K) E1B protein, however, the …

In the evolutionary battle between viruses and their hosts, viruses have armed themselves
with weapons to defeat the host's attacks on infected cells. Various proteins encoded in the …