Replicated international studies have underscored the human and societal costs associated
with major depressive disorder. Despite the proven efficacy of monoamine-based …

Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

Background Ketamine appears to have a therapeutic role in certain mental disorders, most
notably depression. However, the comparative performance of different formulations of …

Although recent years have seen large decreases in the overall global rate of suicide
fatalities, this trend is not reflected everywhere. Suicide and suicidal behaviour continue to …

Suicide is preventable. Nevertheless, each year 800,000 people die of suicide in the world.
While there is evidence indicating that suicide rates de‐crease during times of crises, they …

Abstract (R, S)-ketamine elicits rapid-acting and sustained antidepressant actions in
treatment-resistant patients with depression.(R)-ketamine produces longer-lasting …

The discovery of robust antidepressant actions exerted by the N-methyl-D-aspartate receptor
(NMDAR) antagonist (R, S)-ketamine has been a crucial breakthrough in mood disorder …

Abstract Purpose of Review Bipolar disorder has the highest rate of suicide of all psychiatric
conditions and is approximately 20–30 times that of the general population. The purpose of …

Ketamine is a non-competitive channel blocker of N-methyl-d-aspartate (NMDA) receptors. A
single sub-anaesthetic dose of ketamine produces rapid (within hours) and long-lasting …

Neuropathic pain remains a significant unmet medical need. Several recommendations
have recently been proposed concerning pharmacotherapy, neurostimulation techniques …